A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2017.07.006
Abstract: OBJECTIVE To assess the safety, pharmacokinetics, and exploratory efficacy of SM04690, a novel Wnt pathway inhibitor, as a potential disease modifying treatment for knee osteoarthritis (OA). DESIGN Subjects with Kellgren-Lawrence grade 2-3 knee OA were… read more here.
Keywords: week; osteoarthritis; study; knee ... See more keywords
Osteoarthritis: Wnt inhibitor shows potential as a DMOAD
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2017.164
Abstract: New research demonstrates that SM04690, a small-molecule inhibitor of the Wnt signalling pathway, has potential as a disease-modifying osteoarthritis (OA) drug (DMOAD). “SM04690 was able to induce chondrocyte differentiation and regenerate and protect cartilage both… read more here.
Keywords: inhibitor; wnt; model; dmoad ... See more keywords
SAT0552 Clinical outcomes from a randomized, double-blind, placebo-controlled, phase 2 study of a novel, intra-articular, injectable, WNT pathway inhibitor (SM04690) for the treatment of knee osteoarthritis: week 26 interim analysis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.6382
Abstract: Background Knee osteoarthritis (OA) is characterized by pain, disability and joint deformity due to degradation of articular cartilage and bone remodeling. The Wnt signaling pathway has a role in these cellular processes, and it is… read more here.
Keywords: samumed llc; clinical outcomes; analysis; treatment ... See more keywords
OP0137 OPTIMIZING SUBJECT SELECTION IN KNEE OSTEOARTHRITIS CLINICAL TRIALS BY RADIOGRAPHIC JOINT SPACE WIDTH: POST-HOC CLINICAL RESPONSE ANALYSIS FROM A PHASE 2B TRIAL OF WNT PATHWAY INHIBITOR, SM04690
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.5219
Abstract: Background Knee osteoarthritis (OA) trial radiographic inclusion criteria usually comprises Kellgren-Lawrence (KL) grading, which mixes features such as osteophytes and joint space narrowing and leads to study population heterogeneity. Selecting subjects with baseline medial joint… read more here.
Keywords: post hoc; samumed llc; analysis; joint space ... See more keywords