PDLIM2 can inactivate the TGF-β/Smad pathway to inhibit the malignant behavior of ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3801
Abstract: PDZ-LIM domain-containing Protein 2 (PDLIM2) has been reported to be downregulated in ovarian cancer. However, its exact function and mechanism in regulating ovarian cancer progression have not been elucidated. This work researched the exert effect… read more here.
Keywords: cancer; tgf smad; ovarian cancer; pdlim2 ... See more keywords
Ginsenoside Rh1 regulates gastric cancer cell biological behaviours and transplanted tumour growth in nude mice via the TGF‐β/Smad pathway
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13708
Abstract: Gastric cancer (GC) is one of the most prevalent malignancies of the digestive tract. Ginsenoside Rh1 was reported to exert effects on GC. The current study set out to explore the mechanism underlying Ginsenoside Rh1… read more here.
Keywords: ginsenoside rh1; tgf smad; rh1; smad pathway ... See more keywords
DANCR‐mediated microRNA‐665 regulates proliferation and metastasis of cervical cancer through the ERK/SMAD pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.13921
Abstract: Emerging evidence has indicated that microRNAs (miRNAs) play an important role in cervical cancer (CC). However, the role of miRNA (miR)‐665 in cervical cancer remains unclear. The aim of the present study was to investigate… read more here.
Keywords: erk smad; mir 665; cervical cancer; smad pathway ... See more keywords
Sinapic Acid Attenuates Hypertrophic Scarring by Modulating the TGF‐β1/Smad Pathway: An In Vivo and In Vitro Investigation
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Clinical Practice"
DOI: 10.1155/ijcp/3671828
Abstract: Hypertrophic scars are formed as a result of excess collagen and fibroblast activity during the tissue healing process and can result in loss of function. Sinapic acid (SA) is a naturally occurring phenolic compound with… read more here.
Keywords: tgf smad; smad pathway; vivo vitro; sinapic acid ... See more keywords
Abstract 3723: Identification and functional characterization of long noncoding RNAs that regulate TGF--Smad pathway as Smad co-factors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3723
Abstract: TGF-β-Smad pathway participates in various biological processes such as development, differentiation, growth regulation, and cancer progression including epithelial-mesenchymal transition (EMT). Long non-coding RNAs (lncRNAs) also involved in carcinogenesis and cancer malignancies. To identify lncRNAs regulating… read more here.
Keywords: tgf smad; high expression; expression; smad pathway ... See more keywords
Abstract P2019: (Pro)Renin Receptor-Dependent Induction of Pro-Fibrotic Factors is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Mouse Renal Collecting Duct Cells
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2019
Abstract: The binding of prorenin to the (pro)renin receptor (PRR) stimulates MAPK/ERK1/2, cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), transforming growth factor-β (TGF-β), pro-fibrotic factors connecting tissue growth factor (CTGF), and plasminogen activator inhibitor… read more here.
Keywords: cox; pro renin; smad pathway; receptor ... See more keywords
Therapeutic effects of kartogenin on temporomandibular joint injury by activating the TGF-β/SMAD pathway in rats.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental biology and medicine"
DOI: 10.1177/15353702231157945
Abstract: Patients with temporomandibular dysfunction (TMD) usually suffer from pathology or malpositioning of the temporomandibular joint (TMJ) disk, leading to the degenerative lesion of condyles. Kartogenin can promote the repair of damaged cartilage. This study aimed… read more here.
Keywords: kartogenin; found kartogenin; tgf smad; temporomandibular joint ... See more keywords
SULF1 expression is increased and promotes fibrosis through the TGF-β1/SMAD pathway in idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05698-3
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease of unknown etiology. Despite the increasing global incidence and poor prognosis, the exact pathogenic mechanisms remain elusive. Currently, effective therapeutic targets and treatment… read more here.
Keywords: tgf smad; fibrosis; smad pathway; sulf1 ... See more keywords
ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway
Sign Up to like & getrecommendations! Published in 2022 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2022e11989
Abstract: Pancreatic cancer (PC) is one of the malignant tumors with the worst prognosis worldwide because of a lack of early diagnostic markers and efficient therapies. Integrin, beta-like 1 (ITGBL1) is a β-integrin-related extracellular matrix protein… read more here.
Keywords: jdp2; pancreatic cancer; itgbl1; smad pathway ... See more keywords
Inhibition of the proliferation, invasion, migration, and epithelial-mesenchymal transition of prostate cancer cells through the action of ATP1A2 on the TGF-β/Smad pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Translational andrology and urology"
DOI: 10.21037/tau-21-1117
Abstract: Background Prostate cancer (PC) is one of the major male malignancies worldwide. Because Na+-K+-ATPase is widely involved in various pathological processes, but the action of its α2 subtype (ATP1A2) in PC is unclear, we investigated… read more here.
Keywords: smad pathway; proliferation; migration; tgf smad ... See more keywords
FAST1 Predicts Poor Survival of Renal Carcinoma and Promotes Its Progression Through the TGF-β/Smad Pathway
Sign Up to like & getrecommendations! Published in 2021 at "OncoTargets and therapy"
DOI: 10.2147/ott.s288847
Abstract: Purpose Renal carcinoma (RC) originates in the renal tubular epithelial system, among which renal cell carcinoma (RCC) is the most frequent one. The forkhead activin signal transducer 1 (FAST1) has been shown to interfere with… read more here.
Keywords: fast1; tgf smad; smad pathway; renal carcinoma ... See more keywords