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   Articles with "smad signaling" as a keyword



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Dysfunction of Caveolae‐Mediated Endocytic TβRI Degradation Results in Hypersensitivity of TGF‐β/Smad Signaling in Osteogenesis Imperfecta

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recommendations! Published in 2022 at "Journal of Bone and Mineral Research"

DOI: 10.1002/jbmr.4734

Abstract: Osteogenesis imperfecta (OI) is a genetic disorder caused by mutations of type I collagen‐related genes, and excessive transforming growth factor‐beta (TGF‐β) signaling is a common mechanism. TGF‐β/Smad signaling has inhibitory effects on osteoblast differentiation and… read more here.

Keywords: smad signaling; caveolae mediated; tgf smad; degradation ... See more keywords
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Kaempferol 3‐O‐gentiobioside, an ALK5 inhibitor, affects the proliferation, migration, and invasion of tumor cells via blockade of the TGF‐β/ALK5/Smad signaling pathway

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recommendations! Published in 2021 at "Phytotherapy Research"

DOI: 10.1002/ptr.7278

Abstract: Overactivation of TGF‐β/ALK5/Smad signaling pathway has been observed in the advanced stage of various human malignancies. As a key component of TGF‐β/ALK5/Smad signaling pathway transduction, TGF‐β type I receptor (also known as ALK5) has emerged… read more here.

Keywords: alk5; tgf alk5; smad signaling; signaling pathway ... See more keywords
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Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-β/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio.

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recommendations! Published in 2019 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2019.01.045

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Curcuma wenyujin Y.H.(CW)，a variety to Curcumae Rhizoma, documented in China Pharmacopeia, has long been used as plant medicine for its traditional effect on promoting Qi, activating blood stagnation and expelling blood stasis. Nowadays,… read more here.

Keywords: fibrosis; tgf smad; curcuma wenyujin; smad signaling ... See more keywords
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Stevioside inhibits transforming growth factor-β1-induced cardiac fibroblast differentiation and collagen synthesis by modulation of Smad signaling pathway

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recommendations! Published in 2018 at "Journal of Functional Foods"

DOI: 10.1016/j.jff.2018.09.004

Abstract: Abstract Stevioside, a low calorie sweetener used in food and beverage, has some beneficial effects. However, the inhibitory effect of stevioside on cardiac fibrosis has not been reported yet. This study aimed to investigate the… read more here.

Keywords: collagen; differentiation collagen; transforming growth; smad signaling ... See more keywords
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Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway.

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recommendations! Published in 2020 at "Toxicology and applied pharmacology"

DOI: 10.1016/j.taap.2020.114882

Abstract: Pulmonary fibrosis is a prototypic chronic progressive lung disease with high morbidity and mortality worldwide. Novel effective therapeutic agents are urgently needed owing to the limited treatment options in clinic. Herein, nagilactone D (NLD), a… read more here.

Keywords: fibrosis; blm induced; vivo; smad signaling ... See more keywords
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Fucosyltransferase 2 induced epithelial‐mesenchymal transition via TGF‐&bgr;/Smad signaling pathway in lung adenocarcinaoma

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recommendations! Published in 2018 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2018.07.026

Abstract: &NA; Fucosyltransferase 2 (FUT2), the enzyme catalyzing &agr;‐1,2‐fucosylation in mammals, has been implicated in cancer. The up‐regulation of FUT2 has been observed in lung adenocarcinoma (LUAD), and FUT2 can enhance the cell migration and invasion… read more here.

Keywords: fut2; bgr smad; bgr; smad signaling ... See more keywords
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Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial–mesenchymal transition via the TGF-β/Smad signaling pathway

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recommendations! Published in 2020 at "Pediatric Research"

DOI: 10.1038/s41390-019-0736-6

Abstract: BACKGROUND Renal fibrosis occurs largely through epithelial–mesenchymal transition (EMT). This study explored the beneficial effects of a human umbilical cord mesenchymal stem cell-loaded decellularized kidney scaffold (ucMSC-DKS) on renal fibrosis in a rodent model of… read more here.

Keywords: fibrosis; tgf smad; smad signaling; signaling pathway ... See more keywords
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A novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-β/Smad signaling

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recommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-020-0142-x

Abstract: Previous studies by us and others demonstrated that activation of Wnt/β-catenin signaling plays a pathogenic role in chronic kidney diseases (CKD). Wnt co-receptor LRP5 variants are reported to associate with autosomal dominant polycystic kidney disease;… read more here.

Keywords: tgf smad; smad signaling; role; tubulointerstitial fibrosis ... See more keywords
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NRP1 regulates radiation-induced EMT via TGF-β/Smad signaling in lung adenocarcinoma cells

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recommendations! Published in 2020 at "International Journal of Radiation Biology"

DOI: 10.1080/09553002.2020.1793015

Abstract: Abstract Purpose Radiation has been shown to promote the epithelial–mesenchymal transition (EMT) in tumor cells, and TGF-β/Smad and PI3K-Akt signaling pathways play an important role in the EMT. In this study, we investigated the effects… read more here.

Keywords: tgf smad; radiation induced; smad; radiation ... See more keywords
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Copper nanoparticles induce early fibrotic changes in the liver via TGF-β/Smad signaling and cause immunosuppressive effects in rats

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recommendations! Published in 2018 at "Nanotoxicology"

DOI: 10.1080/17435390.2018.1472313

Abstract: Abstract Copper nanoparticles (Cu NPs) have various uses, including as additives in polymers/plastics, lubricants for metallic coating, and biomedical applications. We investigated the role of transforming growth factor (TGF)-β1 signaling in hepatic damage caused by… read more here.

Keywords: fibrotic changes; tgf smad; smad signaling; tgf ... See more keywords
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The effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway

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recommendations! Published in 2018 at "Animal Cells and Systems"

DOI: 10.1080/19768354.2018.1497706

Abstract: ABSTRACT BMP I type receptor inhibitor can selectively inhibit BMP/Smad signaling pathways, mainly by inhibiting the BMP I type receptor activity to prevent phosphorylation of Smad1, Smad5 and Smad9. The aim of the present study… read more here.

Keywords: ovarian granulosa; smad signaling; bmp smad; expression ... See more keywords