Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.02.013
Abstract: Bone morphogenetic protein 2 (BMP2) is a neurotrophic factor which induces the growth of midbrain dopaminergic (DA) neurons in vitro and in vivo, and its neurotrophic effects have been shown to be dependent on activation… read more here.
Keywords: smad signalling; induced smad; endocytosis; bmp2 induced ... See more keywords
Propolis compound inhibits profibrotic TGF-β1/SMAD signalling in human fibroblasts
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-07918-2
Abstract: Hypertrophic scarring of the skin is a cause of pain, disfigurement, and restricted mobility. Excessive TGF-β1 signalling leads to SMAD3 phosphorylation, which is implicated in hypertrophic scarring. In this study, we examined the mechanism of… read more here.
Keywords: smad signalling; hypertrophic scarring; tgf; expression ... See more keywords
Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical biology"
DOI: 10.1080/13880209.2020.1867197
Abstract: CONTEXT Panax ginseng C.A. Meyer (Araliaceae) has cardioprotective effects. Ginsenosides are responsible for most of the pharmacological activities of ginseng. OBJECTIVE This study investigates the effect of ginsenoside Rg2 on myocardial fibrosis in myocardial ischaemia… read more here.
Keywords: smad signalling; myocardial fibrosis; ginsenoside rg2; tgf smad ... See more keywords
PD17 Skin-derived precursor conditioned-medium-alleviated photoageing via early activation of the transforming growth factor-β/Smad signalling pathway by thrombospondin 1: in vitro and in vivo studies
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Dermatology"
DOI: 10.1093/bjd/ljaf085.269
Abstract: Photoageing is one major exogenous factor of skin ageing. Our previous studies indicated that skin-derived precursors (SKPs) alleviated photodamage by early activation of the transforming growth factor (TGF)-β/Smad signalling pathway via thrombospondin 1 (TSP1). However,… read more here.
Keywords: smad signalling; factor; signalling pathway; growth ... See more keywords
Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling
Sign Up to like & getrecommendations! Published in 2024 at "Experimental Dermatology"
DOI: 10.1111/exd.15133
Abstract: The management of hypertrophic scars (HSs), characterized by excessive collagen production, involves various nonsurgical and surgical interventions. However, the absence of a well‐defined molecular mechanism governing hypertrophic scarring has led to less‐than‐ideal results in clinical… read more here.
Keywords: tgf smad; fibrosis; smad signalling; decorin ... See more keywords
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF‐β/Smad signalling in type 2 diabetic rats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16601
Abstract: Diabetic cardiomyopathy (DCM) is one of the leading causes of heart failure in patients with diabetes mellitus, with limited effective treatments. The cardioprotective effects of sodium‐glucose cotransporter 2(SGLT2) inhibitors have been supported by amounts of… read more here.
Keywords: smad signalling; fibrosis; tgf smad; cardiac fibrosis ... See more keywords
AANG: A natural compound formula for overcoming multidrug resistance via synergistic rebalancing the TGF‐β/Smad signalling in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16928
Abstract: Cancer cells are high in heterogeneity and versatility, which can easily adapt to the external stresses via both primary and secondary resistance. Targeting of tumour microenvironment (TME) is a new approach and an ideal therapeutic… read more here.
Keywords: medicine; smad signalling; formula; resistance ... See more keywords
Transcriptomics and Proteomics Reveal That TLPW Acupuncture Ameliorates Proteinuria in Diabetic Kidney Disease Model Rats by Suppressing Epithelial-to-Mesenchymal Transition via the DPP4/SDF-1α/TGF-β/Smad Signalling Axis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Diabetes Research"
DOI: 10.1155/jdr/2379872
Abstract: Ten male Sprague–Dawley rats were randomly assigned to serve as the negative control (NC) group, and 50 others were maintained on a high-fat diet (HFD). After 18 weeks of feeding, the HFD group received streptozotocin… read more here.
Keywords: tgf smad; smad signalling; acupuncture; group ... See more keywords
Six1 Promotes Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells via the TGFβ1/Smad Signalling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000512873
Abstract: Introduction: The homeodomain transcription factor sine oculis homeobox homolog 1 (Six1) plays a crucial role in embryogenesis and is not expressed in normal adult tissue but is expressed in many pathological processes, including airway remodelling… read more here.
Keywords: smad signalling; tgf smad; six1; signalling pathway ... See more keywords
TGF-β/Smad Signalling Activation by HTRA1 Regulates the Function of Human Lens Epithelial Cells and Its Mechanism in Posterior Subcapsular Congenital Cataract
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214431
Abstract: Congenital cataract is the leading cause of blindness among children worldwide. Patients with posterior subcapsular congenital cataract (PSC) in the central visual axis can result in worsening vision and stimulus deprivation amblyopia. However, the pathogenesis… read more here.
Keywords: congenital cataract; htra1; lens epithelial; tgf smad ... See more keywords