17β-estradiol promotes angiogenesis through non-genomic activation of Smad1 signaling in endometriosis.
Sign Up to like & getrecommendations! Published in 2021 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2021.106932
Abstract: 17β-estradiol (E2) plays a key role in endometriosis through regulation of angiogenesis. Smad1 has been reported to be up-regulated in patients with endometriosis. However, the role of Smad1 in E2-mediated angiogenesis during the development of… read more here.
Keywords: endometriosis; estradiol; smad1; smad1 signaling ... See more keywords
Berberine inhibits osteogenic differentiation of aortic valve interstitial cells by interfering Smad1/5/8 and NF-κB pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2022.106986
Abstract: AIMS Calcified aortic valve disease (CAVD) is a cardiovascular disease with increasing morbidity and mortality. The pathogenetic cellular mechanism is the phenotype transition of aortic valve interstitial cells (VICs). Here, we explored the effect of… read more here.
Keywords: osteogenic differentiation; aortic valve; valve interstitial; smad1 ... See more keywords
AGEs inhibit scavenger receptor class B type I gene expression via Smad1 in HUVECs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-20-0177
Abstract: Vascular complications are the main cause of morbidity and mortality in diabetic patients, and advanced glycation end products (AGEs) play a critical role in promoting diabetic vascular dysfunction. The human homolog of scavenger receptor class… read more here.
Keywords: expression; hsr cla; smad1; receptor ... See more keywords
SMAD1 promoter hypermethylation and lack of SMAD1 expression in Hodgkin lymphoma: a potential target for hypomethylating drug therapy
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2020.249276
Abstract: Hodgkin lymphoma (HL) is an immunologically active lymphoid neoplasm composed of a few (usually 1-10%) neoplastic Hodgkin and Reed-Sternberg (HRS) cells or lymphocyte-predominant (LP) cells and >90% non-neoplastic cells, mainly Tand B-lymphocytes, plasma cells, macrophages,… read more here.
Keywords: hrs cells; tumor; smad1 expression; smad1 ... See more keywords
Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP‑Smad1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7543
Abstract: The aim of the present study was to investigate the effects of mechanical stress on the osteogenic differentiation of human ligamentum flavum cells via the bone morphogenetic protein (BMP)‑Smad1 signaling pathway. Mechanical stress increased cell proliferation… read more here.
Keywords: mechanical stress; differentiation human; stress; osteogenic differentiation ... See more keywords