17β-estradiol promotes angiogenesis through non-genomic activation of Smad1 signaling in endometriosis.
Sign Up to like & getrecommendations! Published in 2021 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2021.106932
Abstract: 17β-estradiol (E2) plays a key role in endometriosis through regulation of angiogenesis. Smad1 has been reported to be up-regulated in patients with endometriosis. However, the role of Smad1 in E2-mediated angiogenesis during the development of… read more here.
Keywords: endometriosis; estradiol; smad1; smad1 signaling ... See more keywords
Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis
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DOI: 10.3390/ijms22168472
Abstract: Adipose tissues (AT) expand in response to energy surplus through adipocyte hypertrophy and hyperplasia. The latter, also known as adipogenesis, is a process by which multipotent precursors differentiate to form mature adipocytes. This process is… read more here.
Keywords: feedback loop; adipogenesis; 3t3 adipogenesis; activation ... See more keywords
BMP-7 suppresses excessive scar formation by activating the BMP-7/Smad1/5/8 signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.6779
Abstract: Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein-7 (BMP-7) has been proved to inhibit TGF-β-induced fibrosis in various tissues including… read more here.
Keywords: bmp smad1; scar; smad1 signaling; scar formation ... See more keywords