Latent membrane protein 2A inhibits expression level of Smad2 through regulating miR‐155‐5p in EBV‐associated gastric cancer cell lines
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25579
Abstract: Epstein‐Barr virus (EBV) infection is one of the causes of gastric cancer (GC). Besides, previous studies have demonstrated that EBV‐encoded latent membrane protein 2A (LMP2A) influences the pathogenesis of EBV‐associated gastric cancer (EBVaGC) through regulating… read more here.
Keywords: protein; mir 155; gastric cancer; cell ... See more keywords
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
Sign Up to like & getrecommendations! Published in 2021 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2021.08.027
Abstract: The SMAD protein family plays crucial roles in reproduction as a downstream target genes of the TGFβ signaling pathway. Many studies have focused on the expression change exploration of SMADs during testicular development and investigation… read more here.
Keywords: testicular development; expression; cell; synthesis ... See more keywords
Smad2 and Smad3 play antagonistic roles in high glucose-induced renal tubular fibrosis via the regulation of SnoN.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104375
Abstract: Diabetic nephropathy (DN) is a serious microvascular complication of diabetes mellitus.The main pathological features of DN include glomerular sclerosis and renal tubular interstitial fibrosis, which results in epithelial mesenchymal transition (EMT) and excessive extracellular matrix… read more here.
Keywords: fibrosis; high glucose; renal tubular; smad2 smad3 ... See more keywords
Elevated TGF-β1 impairs synaptic and cognitive function through activation of Smad2/3-Sp1 pathway in AngII-related hypertension
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Reports"
DOI: 10.1038/s44319-025-00470-0
Abstract: Vascular dementia (VaD) is characterized by cognitive decline due to reduced cerebral blood flow, although its molecular mechanisms remain unclear. This study shows that angiotensin II (AngII) elevates blood pressure, reduces hippocampal blood flow, and… read more here.
Keywords: smad2; sp1; tgf; synaptic cognitive ... See more keywords
Stevioside inhibits lipopolysaccharide-induced epithelial-to-mesenchymal transition of NRK-52E cells by PPARγ activation
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2039935
Abstract: Abstract Background Stevioside is a natural diterpenoid compound that possesses anti-inflammatory, immunomodulatory, anti-diabetic, anti-hypertensive, and renal protective effects, but its effect on lipopolysaccharide (LPS)-induced epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells, an important immune… read more here.
Keywords: mesenchymal transition; nrk 52e; smad2; epithelial mesenchymal ... See more keywords
Family with sequence similarity 46 member a confers chemo-resistance to ovarian carcinoma via TGF-β/Smad2 signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2064652
Abstract: Ovarian cancer is the most lethal malignancy with depressive 5-year survival rate, mainly due to patients with advanced stages experience tumor recurrence and resistance to the current chemotherapeutic agents. Thus, exploring the underlying molecular mechanisms… read more here.
Keywords: smad2; ovarian cancer; chemo resistance; cancer ... See more keywords
Liraglutide Promotes the Osteogenic Differentiation in MC3T3-E1 Cells Via Regulating the Expression of Smad2/3 Through PI3K/Akt and Wnt/β-Catenin Pathways.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2018.4397
Abstract: Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance between bone resorption and formation resulted in the structural integrity and strength of bone.… read more here.
Keywords: akt; bone; differentiation; osteogenic differentiation ... See more keywords
GP73 promotes epithelial–mesenchymal transition and invasion partly by activating TGF-&bgr;1/Smad2 signaling in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Carcinogenesis"
DOI: 10.1093/carcin/bgy010
Abstract: The transforming growth factor-β1 (TGF-β1) signaling pathways contribute to cell metastasis and epithelial-mesenchymal transition (EMT). Golgi protein 73 (GP73), a type II transmembrane protein in the Golgi apparatus, was initially regarded as a potential biomarker… read more here.
Keywords: hcc; invasion; gp73; metastasis ... See more keywords
Abstract 2032: CXCR7 promotes the migration and invasion of head and neck squamous cell carcinoma through Smad2/Akt signaling
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2032
Abstract: Background: The chemokine receptor, CXCR7, has been shown to play an important role in the progression of several types of cancer. However, there have been few reports on the biological role of CXCR7 in head… read more here.
Keywords: hnscc; cell; cxcr7; migration invasion ... See more keywords
Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-β/Smad2 signaling in chondrocytes
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.166688
Abstract: TGF-β signaling is crucial for modulating osteoarthritis (OA), and protein phosphatase magnesium–dependent 1A (PPM1A) has been reported as a phosphatase of SMAD2 and regulates TGF-β signaling, while the role of PPM1A in cartilage homeostasis and… read more here.
Keywords: smad2; tgf smad2; smad2 signaling; protein phosphatase ... See more keywords
Differential regulations of fibronectin and laminin in Smad2 activation in vascular endothelial cells in response to disturbed flow
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-017-0402-4
Abstract: BackgroundAtherosclerosis occurs in arterial curvatures and branches, where the flow is disturbed with low and oscillatory shear stress (OSS). The remodeling and alterations of extracellular matrices (ECMs) and their composition is the critical step in… read more here.
Keywords: fibronectin laminin; response; vascular endothelial; endothelial cells ... See more keywords