KIN17 promotes cell migration and invasion through stimulating the TGF‐β/Smad2 pathway in hepatocellular carcinoma
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DOI: 10.1002/mc.23492
Abstract: KIN17 DNA and RNA binding protein (Kin17) is involved in the regulation of tumorigenesis of diverse human cancers. However, its role in the cancer progression and metastasis in hepatocellular carcinoma (HCC) remains largely unknown. Bioinformatics… read more here.
Keywords: smad2 pathway; migration invasion; kin17; tgf smad2 ... See more keywords
Efficacy and Clinical Significance of the Zuogui Pill on Premature Ovarian Failure via the GDF-9/Smad2 Pathway
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DOI: 10.1080/01635581.2022.2123531
Abstract: Abstract Our study aims to investigate the efficacy and clinical significance of the Zuogui pill (ZGP) on premature ovarian failure (POF) via the GDF-9/Smad2 pathway. Changes in clinical symptoms in the control group (treated with… read more here.
Keywords: gdf smad2; clinical significance; efficacy clinical; gdf ... See more keywords
Smad2/3‐pathway ligand trap luspatercept enhances erythroid differentiation in murine β‐thalassaemia by increasing GATA‐1 availability
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DOI: 10.1111/jcmm.15243
Abstract: In β‐thalassaemia, anaemia results from ineffective erythropoiesis characterized by inhibition of late‐stage erythroid differentiation. We earlier used luspatercept and RAP‐536 protein traps for certain Smad2/3‐pathway ligands to implicate Smad2/3‐pathway overactivation in dysregulated erythroid differentiation associated… read more here.
Keywords: smad2 pathway; erythroid differentiation; differentiation; murine thalassaemia ... See more keywords
Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway
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DOI: 10.2147/dddt.s264715
Abstract: Purpose Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix (ECM) protein in the lungs. Transforming growth factor (TGF) β-induced ECM protein synthesis contributes to the development of IPF. Tranilast, an anti-allergy… read more here.
Keywords: tranilast inhibits; fibrosis; pulmonary fibrosis; smad2 pathway ... See more keywords