Smad2 and Smad3 play antagonistic roles in high glucose-induced renal tubular fibrosis via the regulation of SnoN.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104375
Abstract: Diabetic nephropathy (DN) is a serious microvascular complication of diabetes mellitus.The main pathological features of DN include glomerular sclerosis and renal tubular interstitial fibrosis, which results in epithelial mesenchymal transition (EMT) and excessive extracellular matrix… read more here.
Keywords: fibrosis; high glucose; renal tubular; smad2 smad3 ... See more keywords
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental animals"
DOI: 10.1538/expanim.21-0064
Abstract: Endothelial-to-mesenchymal transition (EndMT) is involved in cardiac fibrosis induced by angiotensin II (Ang II). A disintegrin and metalloproteinase 8 (ADAM8), a member of ADAMs family, participates in cell adhesion, proteolysis and various signaling. However, its… read more here.
Keywords: tgf smad2; induced cardiac; fibrosis; cardiac fibrosis ... See more keywords
Expression and Polymorphisms of SMAD1, SMAD2 and SMAD3 Genes and Their Association with Litter Size in Tibetan Sheep (Ovis aries)
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13122307
Abstract: SMAD1, SMAD2, and SMAD3 are important transcription factors downstream of the TGF-β/SMAD signaling pathway that mediates several physiological processes. In the current study, we used cloning sequencing, RT-qPCR, bioinformatics methods and iMLDR technology to clone… read more here.
Keywords: smad2 smad3; tibetan sheep; litter size; smad1 smad2 ... See more keywords