Smad3 promotes adverse cardiovascular remodeling and dysfunction in doxorubicin-treated hearts
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Heart and Circulatory Physiology"
DOI: 10.1152/ajpheart.00312.2022
Abstract: Many anticancer therapies cause serious cardiovascular complications that degrade quality of life and cause early mortality in treated patients. Specifically, doxorubicin is known as an effective anticancer agent that causes cardiomyopathy in treated patients. There… read more here.
Keywords: cell; endothelial cells; doxorubicin; physiology ... See more keywords
miR-154-5p Affects the TGFβ1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7502632
Abstract: Aim The study is aimed at verifying miR-154-5p and Smurf1 combination in glomerular mesangial cells regulating TGFβ1/Smad3 pathway-related protein ubiquitination in the model of diabetic rats renal tissues, primary mesangial cells, and cell lines. Methods… read more here.
Keywords: tgf smad3; smurf1; mir 154; diabetic kidney ... See more keywords
CyPA interacts with SERPINH1 to promote extracellular matrix production and inhibit epithelial-mesenchymal transition of trophoblast via enhancing TGF-β/Smad3 pathway in preeclampsia
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DOI: 10.2139/ssrn.3967220
Abstract: We previously reported that cyclophilin A (CyPA) production is upregulated in preeclampsia (PE). Moreover, CyPA is known to induce PE-like features in pregnant mice and impair trophoblast invasiveness. In this study, we further illustrated the… read more here.
Keywords: extracellular matrix; mesenchymal transition; smad3 pathway; tgf smad3 ... See more keywords
Follistatin Attenuates Myocardial Fibrosis in Diabetic Cardiomyopathy via the TGF-β–Smad3 Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.683335
Abstract: Follistatin (FST) is an endogenous protein that irreversibly inhibits TGF-β superfamily members and plays an anti-fibrotic role in other diseases. However, the role of FST in diabetic cardiomyopathy remains unclear. In this study, we investigated… read more here.
Keywords: fibrosis; fst; diabetic cardiomyopathy; smad3 pathway ... See more keywords