Allicin induced AMPK signaling attenuated Smad3 pathway mediated lung fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-01314-6
Abstract: Allicin, a natural compound derived from garlic, protects against oxidative stress-mediated tissue inflammation and vascular remodeling. Although these are key processes in lung fibrosis, the effects of allicin on this disease have never been evaluated.… read more here.
Keywords: fibrosis; effects allicin; smad3 pathway; mediated lung ... See more keywords
CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway in intrauterine adhesion
Sign Up to like & getrecommendations! Published in 2024 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioae016
Abstract: Abstract Intrauterine adhesion (IUA) is manifestations of endometrial fibrosis and excessive extracellular matrix deposition. C1q/tumor necrosis factor-related protein-6 (CTRP6) is a newly identified adiponectin paralog which has been reported to modulate the fibrosis process of… read more here.
Keywords: ctrp6; fibrosis; smad3 pathway; intrauterine adhesion ... See more keywords
Smad3 promotes adverse cardiovascular remodeling and dysfunction in doxorubicin-treated hearts
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Heart and Circulatory Physiology"
DOI: 10.1152/ajpheart.00312.2022
Abstract: Many anticancer therapies cause serious cardiovascular complications that degrade quality of life and cause early mortality in treated patients. Specifically, doxorubicin is known as an effective anticancer agent that causes cardiomyopathy in treated patients. There… read more here.
Keywords: cell; endothelial cells; doxorubicin; physiology ... See more keywords
miR-154-5p Affects the TGFβ1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7502632
Abstract: Aim The study is aimed at verifying miR-154-5p and Smurf1 combination in glomerular mesangial cells regulating TGFβ1/Smad3 pathway-related protein ubiquitination in the model of diabetic rats renal tissues, primary mesangial cells, and cell lines. Methods… read more here.
Keywords: tgf smad3; smurf1; mir 154; diabetic kidney ... See more keywords
Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05540-w
Abstract: Synovial fibrosis is a common complication of knee osteoarthritis (KOA), a pathological process characterized by myofibroblast activation and excessive extracellular matrix (ECM) deposition. Fibroblast-like synoviocytes (FLSs) are implicated in KOA pathogenesis, contributing to synovial fibrosis… read more here.
Keywords: fibrosis; synovial fibrosis; fibroblast like; smad3 pathway ... See more keywords
MiR-10b-5p attenuates spinal cord injury and alleviates LPS-induced PC12 cells injury by inhibiting TGF-β1 decay and activating TGF-β1/Smad3 pathway through PTBP1
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Medical Research"
DOI: 10.1186/s40001-024-02133-7
Abstract: Spinal cord injury (SCI) is a debilitating condition characterized by significant sensory, motor, and autonomic dysfunctions, leading to severe physical, psychological, and financial burdens. The current therapeutic approaches for SCI show limited effectiveness, highlighting the… read more here.
Keywords: pc12 cells; spinal cord; mir 10b; smad3 pathway ... See more keywords
CyPA interacts with SERPINH1 to promote extracellular matrix production and inhibit epithelial-mesenchymal transition of trophoblast via enhancing TGF-β/Smad3 pathway in preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Endocrinology"
DOI: 10.2139/ssrn.3967220
Abstract: We previously reported that cyclophilin A (CyPA) production is upregulated in preeclampsia (PE). Moreover, CyPA is known to induce PE-like features in pregnant mice and impair trophoblast invasiveness. In this study, we further illustrated the… read more here.
Keywords: extracellular matrix; mesenchymal transition; smad3 pathway; tgf smad3 ... See more keywords
Follistatin Attenuates Myocardial Fibrosis in Diabetic Cardiomyopathy via the TGF-β–Smad3 Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.683335
Abstract: Follistatin (FST) is an endogenous protein that irreversibly inhibits TGF-β superfamily members and plays an anti-fibrotic role in other diseases. However, the role of FST in diabetic cardiomyopathy remains unclear. In this study, we investigated… read more here.
Keywords: fibrosis; fst; diabetic cardiomyopathy; smad3 pathway ... See more keywords
Silencing Map3k7 suppresses pyroptosis to alleviate bronchopulmonary dysplasia through inhibiting the TGF-β1/Smad3 pathway.
Sign Up to like & getrecommendations! Published in 2025 at "General physiology and biophysics"
DOI: 10.4149/gpb_2024043
Abstract: Bronchopulmonary dysplasia (BPD) is a serious complication in premature infants. This study aimed to investigate the mechanism of mitogen-activated protein 3 kinase 7 (Map3k7) affecting BPD by regulating caspase-1 mediated pyroptosis. The morphology of the… read more here.
Keywords: silencing map3k7; map3k7; smad3 pathway; bpd ... See more keywords