TRPV4 Mediates Cardiac Fibrosis via the TGF-β1/Smad3 Signaling Pathway in Diabetic Rats
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-020-09572-8
Abstract: Emerging evidence shows that the transient receptor potential vanilloid 4 (TRPV4) channel is involved in fibrosis in many organs. However, its role in diabetic cardiac fibrosis remains unclear. Our aim was to evaluate the expression… read more here.
Keywords: smad3 signaling; fibrosis; cardiac fibrosis; tgf smad3 ... See more keywords
Klotho down-regulates Egr-1 by inhibiting TGF-β1/Smad3 signaling in high glucose treated human mesangial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.036
Abstract: Diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease worldwide and is associated with glomerular mesangial cell (MC) proliferation and excessive extracellular matrix (ECM) production. Klotho can attenuate renal fibrosis in… read more here.
Keywords: high glucose; smad3; smad3 signaling; expression ... See more keywords
Edaravone attenuates lipopolysaccharide-induced acute respiratory distress syndrome associated early pulmonary fibrosis via amelioration of oxidative stress and transforming growth factor-β1/Smad3 signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.165
Abstract: Pulmonary fibrosis is responsible for the both short-term and long-term outcomes in patients with acute respiratory distress syndrome (ARDS). There is still no effective cure to improve prognosis. The purpose of this study was to… read more here.
Keywords: fibrosis; associated early; smad3 signaling; pulmonary fibrosis ... See more keywords
Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.09.015
Abstract: Hesperidin is a plant-derived bioflavonoid with promising antitumor efficacy, though the underlying mechanisms of action remain poorly elucidated. Thus, we evaluated the in vivo chemopreventive effect of hesperidin against diethylnitrosamine (DEN)-induced hepatocarcinogenesis. We demonstrated the modulatory… read more here.
Keywords: smad3; smad3 signaling; hesperidin; nrf2 ppar ... See more keywords
Functional importance of the TGF-β1/Smad3 signaling pathway in oxygen-glucose-deprived (OGD) microglia and rats with cerebral ischemia.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.113
Abstract: We investigated the transforming growth factor-b1 (TGF-β1)/Smad3 signaling pathway in rats with cerebral ischemia and oxygen-glucose-deprived (OGD) microglia. Cerebral ischemia is a clinical condition that occurs when insufficient blood flows to the brain to maintain… read more here.
Keywords: cerebral ischemia; smad3; smad3 signaling; expression ... See more keywords
Paeonol alleviates CCl4-induced liver fibrosis through suppression of hepatic stellate cells activation via inhibiting the TGF-β/Smad3 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2019.1613427
Abstract: Abstract Objective: Paeonol is a natural phenolic component isolated from the root bark of peony with multiple pharmacological activities. We investigated the anti-fibrotic effect and underlying mechanism of paeonol. Methods: Twenty-four male C57BL/6J mice were… read more here.
Keywords: paeonol; smad3 signaling; tgf smad3; liver fibrosis ... See more keywords
Simulated microgravity altered the proliferation, apoptosis, and extracellular matrix formation of L929 fibroblasts and the transforming growth factor‐β1/Smad3 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Skin Research and Technology"
DOI: 10.1111/srt.13341
Abstract: Exposure to microgravity can adversely affect the fitness of astronauts. The integrity of the skin plays a crucial role in protecting against mechanical forces and infections, fluid imbalance, and thermal dysregulation. In brief, the skin… read more here.
Keywords: smad3 signaling; microgravity; signaling pathway; growth ... See more keywords
All-trans retinoic acid inhibits lipopolysaccharide-induced inflammatory responses in bovine adipocytes via TGFβ1/Smad3 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "BMC Veterinary Research"
DOI: 10.1186/s12917-019-1791-2
Abstract: BackgroundDairy cows with metabolic disorder in peripartal period display high inflammatory levels. Adipose tissue is a major endocrine organ, which is closely related to systemic inflammation. Retinoic acid (RA), an active metabolite of vitamin A,… read more here.
Keywords: inflammatory responses; bovine adipocytes; signaling pathway; smad3 signaling ... See more keywords
Canagliflozin alleviates high glucose-induced peritoneal fibrosis via HIF-1α inhibition
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1152611
Abstract: The cardioprotective effects of sodium-glucose cotransporter type 2 (SGLT2) inhibitors have been demonstrated in many studies. However, their benefits for end-stage kidney disease patients, particularly those on peritoneal dialysis, remain unclear. SGLT2 inhibition has shown… read more here.
Keywords: peritoneal fibrosis; smad3 signaling; high glucose; tgf smad3 ... See more keywords