Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation
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DOI: 10.1038/s41388-022-02293-y
Abstract: SMAD4 loss-of-function mutations have been frequently observed in colorectal cancer (CRC) and are recognized as a drug target for therapeutic exploitation. In this study, we performed a synthetic lethal drug screening with SMAD4-isogenic CRC cells… read more here.
Keywords: crc cells; crc; smad4 crc; smad4 ... See more keywords