Discovery of Novel Cyclic Peptides as SMAD2-SMAD4 Interaction Inhibitors for the Treatment of Hepatic Fibrosis.
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DOI: 10.1021/acs.jmedchem.4c02938
Abstract: Hepatic fibrosis, characterized by the excessive deposition of the extracellular matrix, represents a common consequence of various chronic liver disorders. However, no specific drugs are available for antifibrotic therapy to date. SMAD2 is phosphorylated by… read more here.
Keywords: fibrosis; hepatic fibrosis; smad4 interaction; novel cyclic ... See more keywords