RGFP966, a Histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114118
Abstract: Glioma stem cells (GSC) play a major role in drug resistance and tumor recurrence. Using a genetic screen with a set of shRNAs that can target chromatin regulators in a GSC model, we have HDAC3… read more here.
Keywords: inhibitor; glioma stem; differentiation; tgf signaling ... See more keywords
Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101470
Abstract: Summary Transforming growth factor β (TGF-β) enhances migration and invasion of cancer cells, causing life-threatening metastasis. Smad7 expression is induced by TGF-β to control TGF-β signaling in a negative feedback manner. Here we report an… read more here.
Keywords: cancer; jun hdac6; smad7; prostate cancer ... See more keywords
Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-β signaling
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02275-0
Abstract: Glioblastoma (GBM) is the most aggressive primary brain tumor as one of the deadliest cancers. The TGF-β signaling acts as an oncogenic factor in GBM, and plays vital roles in development of GBM. SMAD7 is… read more here.
Keywords: development; glioblastoma; linked poly; smad7 ... See more keywords
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2054224
Abstract: ABSTRACT Liver fibrosis resulting from chronic liver injuries (CLI) is a common health problem globally. Guizhi Fuling pill (GZFL), a modern preparation from traditional Chinese medicine, exhibited anti-dysmenorrhea, anti-inflammatory, and immune-regulative effects. However, the effect… read more here.
Keywords: fibrosis; liver fibrosis; tgf smad2; smad7 ... See more keywords
Reduced expression of SMAD7 and consequent reduction of autophagy promotes endometrial stromal-myofibroblast transition and fibrosis.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaae036
Abstract: Abnormal autophagy and the transforming growth factor-β (TGFβ)-SMAD3/7 signaling pathway play an important role in the development of intrauterine adhesions (IUA); however, the exact underlying mechanisms remain unclear. In this study, we used IUA patient… read more here.
Keywords: autophagic flux; fibrosis; smad3; autophagy ... See more keywords
LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac780
Abstract: Abstract Transforming growth factor β (TGF-β) superfamily proteins are potent regulators of cellular development and differentiation. Nodal/Activin/TGF-β and BMP ligands are both present in the intra- and extracellular milieu during early development, and cross-talk between… read more here.
Keywords: cell fate; bmp signaling; smad7; fate determination ... See more keywords
High Smad7 sustains inflammatory cytokine response in refractory coeliac disease
Sign Up to like & getrecommendations! Published in 2017 at "Immunology"
DOI: 10.1111/imm.12690
Abstract: Refractory coeliac disease (RCD) is a form of coeliac disease (CD) resistant to gluten‐free diet and associated with elevated risk of complications. Many effector cytokines over‐produced in the gut of patients with RCD are supposed… read more here.
Keywords: high smad7; coeliac disease; inflammatory cytokine; rcd ... See more keywords
A genetic variant in SMAD7 acts as a modifier of LMNA-associated muscular dystrophy, implicating SMAD signaling as a therapeutic target
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.ads7903
Abstract: Mutations in LMNA cause multiple types of muscular dystrophy (LMNA-MD). The symptoms of LMNA-MD are highly variable and sensitive to genetic background. To identify genetic contributions to this phenotypic variability, we performed whole-genome sequencing on… read more here.
Keywords: variant smad7; muscle; modifier lmna; muscular dystrophy ... See more keywords
Activation of canonical BMP4-SMAD7 signaling suppresses breast cancer metastasis.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0743
Abstract: Metastasis is the major cause of death in cancer patients; with no therapeutic cure, treatments remain largely palliative. As such, new targets and therapeutic strategies are urgently required. Here we show that bone morphogenetic protein-4… read more here.
Keywords: metastasis; smad7; cancer; breast cancer ... See more keywords
Abstract 4363062: BRCC3 inhibition of EndoMT via deubiquitination of Smad7: Implication in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4363062
Abstract: Background: Endothelial-to-mesenchymal transition (EndoMT), driven by the TGF-β/Smad2/3 signaling, contributes to endothelial dysfunction and atherosclerosis. BRCC3 is a K63-dependent deubiquitinase know to downregulate Smad pathways, but its role in EndoMT and atherosclerosis remains unclear. Objective:… read more here.
Keywords: endomt via; deubiquitination; implication atherosclerosis; atherosclerosis ... See more keywords
Metabolic and Epigenetic Regulation of SMAD7 by Stanniocalcin-1 (STC1) Ameliorates Lung Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0445oc
Abstract: As shown in our previous studies, the intratracheal-administration of stanniocalcin-1 (STC1) ameliorates pulmonary fibrosis by reducing oxidative and endoplasmic reticulum stress through the uncoupling of respiration in a bleomycin (BLM)-treated mouse model. However, the overall… read more here.
Keywords: stc1 ameliorates; smad7; stc1; stanniocalcin stc1 ... See more keywords