Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors.
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DOI: 10.1021/acs.jmedchem.2c02037
Abstract: Nuclear factor erythroid-related 2-factor 2 (Nrf2) is a transcription factor traditionally thought of as a cellular protector. However, in many cancers, Nrf2 is constitutively activated and correlated with therapeutic resistance. Nrf2 heterodimerizes with small musculoaponeurotic… read more here.
Keywords: transcription; smaf transcription; peptides direct; transcription factors ... See more keywords