Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells
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DOI: 10.1080/21655979.2022.2045835
Abstract: ABSTRACT The loss of inner ear hair cells leads to irreversible acoustic injury in mammals, and regeneration of inner ear hair cells to restore hearing loss is challenging. ATOH1 is a key gene in the… read more here.
Keywords: hair; inner ear; small activating; hair cells ... See more keywords
Small Activating RNAs: Towards Development of New Therapeutic Agents and Clinical Treatments.
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DOI: 10.2174/1389201019666180802145134
Abstract: BACKGROUND Small double-strand RNAs (dsRNAs) molecules are able to activate endogenous genes via an RNA-based promoter-targeting mechanism. Like RNA interference (RNAi), RNA activation (RNAa) is an evolutionarily conserved mechanism that is present in diverse eukaryotic… read more here.
Keywords: small activating; rnas towards; development new; clinical treatments ... See more keywords