Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr
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DOI: 10.1126/sciadv.adr9624
Abstract: Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial toxin-antitoxin systems that pyrophosphorylate the 3′-CCA end of transfer RNA (tRNA) to prevent aminoacylation. toxSAS are implicated in antiphage immunity: Phage detection triggers the toxSAS… read more here.
Keywords: small alarmone; farel2; trnagly trnathr; toxic small ... See more keywords
Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation
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DOI: 10.1128/mbio.02422-22
Abstract: Small alarmone hydrolases (SAHs) comprise a widespread family of alarmone metabolizing enzymes. In metazoans, SAHs have been reported to control multiple aspects of physiology and stress resistance through alarmone and NADPH metabolisms, but their physiological… read more here.
Keywords: small alarmone; campestris campestris; alarmone; physiology ... See more keywords