Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
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DOI: 10.1021/acs.jmedchem.1c01782
Abstract: We report the synthesis and antibacterial activities of a series of amphiphilic membrane-active peptides composed, in part, of various nongenetically coded hydrophobic amino acids. The lead cyclic peptides, 8C and 9C, showed broad-spectrum activity against… read more here.
Keywords: small amphiphilic; cyclic peptides; amphiphilic peptides; activity ... See more keywords