Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy.
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DOI: 10.1021/acs.jmedchem.4c00553
Abstract: In this work, a series of bifunctional PD-L1/CD73 (cluster of differentiation 73) small-molecule inhibitors were designed and synthesized. Among them, CC-5 showed the strongest PD-L1 inhibitory effects with an IC50 of 6 nM and potent… read more here.
Keywords: cd73; discovery small; small bifunctional; bifunctional molecules ... See more keywords