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   Articles with "small colony" as a keyword



Dual‐Responsive Nanogels with Cascaded Gentamicin Release and Lysosomal Escape to Combat Intracellular Small Colony Variants for Peritonitis and Sepsis Therapies

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202303671

Abstract: Intracellular bacteria are the major cause of serious infections including sepsis and peritonitis, but face great challenges in fighting against the stubborn intracellular small colony variants (SCVs). Herein, the authors have developed nanogels (NGs) to… read more here.

Keywords: sepsis therapies; colony variants; small colony; intracellular small ... See more keywords

Frequency of small-colony variants and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus in cystic fibrosis patients.

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recommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"

DOI: 10.1016/j.diagmicrobio.2017.11.012

Abstract: BACKGROUND Small-colony variants (SCVs) are a distinct phenotype of Staphylococcus aureus, known for their role in chronic, difficult to treat infections, including cystic fibrosis (CF) lung disease. The goal of this study was to characterize… read more here.

Keywords: small colony; mrsa; scv mrsa; colony variants ... See more keywords
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Properties and control of cold-induced small colony variants of Staphylococcus aureus

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recommendations! Published in 2021 at "Food bioscience"

DOI: 10.1016/j.fbio.2020.100874

Abstract: Abstract Staphylococcus aureus can survive at low temperature which existed a potential risk of food safety. In this paper, the properties of cold-induced small colony variants (SCVs) were investigated including the antibiotic resistance, biofilm formation… read more here.

Keywords: staphylococcus aureus; cold induced; small colony; induced small ... See more keywords

Novel Bacterial Diversity and Fragmented eDNA Identified in Hyperbiofilm-Forming Pseudomonas aeruginosa Rugose Small Colony Variant

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recommendations! Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.100827

Abstract: Summary Pseudomonas aeruginosa biofilms represent a major threat to health care. Rugose small colony variants (RSCV) of P. aeruginosa, isolated from chronic infections, display hyperbiofilm phenotype. RSCV biofilms are highly resistant to antibiotics and host… read more here.

Keywords: rugose small; pseudomonas aeruginosa; pao1 wspf; small colony ... See more keywords

Inactivation of genes in oxidative respiration and iron acquisition pathways in pediatric clinical isolates of Small colony variant Enterobacteriaceae

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-86764-4

Abstract: Isolation of bacterial small colony variants (SCVs) from clinical specimens is not uncommon and can fundamentally change the outcome of the associated infections. Bacterial SCVs often emerge with their normal colony phenotype (NCV) co-isolates in… read more here.

Keywords: colony; scv; small colony; iron ... See more keywords

Microbial dormancy evolution in the environments: Environmental adaptation and health risks of small colony variants

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recommendations! Published in 2025 at "Critical Reviews in Environmental Science and Technology"

DOI: 10.1080/10643389.2025.2566174

Abstract: Abstract Natural environmental conditions fluctuate randomly, with various factors influencing multiple aspects of the microorganisms that live in them. In adverse environmental conditions, microorganisms can enter dormant states with low metabolic activities, which is a… read more here.

Keywords: dormancy evolution; colony; small colony; microbial dormancy ... See more keywords

Triclosan-resistant small-colony variants of Staphylococcus aureus produce less capsule, less phenol-soluble modulins, and are attenuated in a Galleria mellonella model of infection

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recommendations! Published in 2023 at "Microbiology"

DOI: 10.1099/mic.0.001277

Abstract: In recent work we identified genes that confer the slow-growing and antibiotic-resistant small-colony variant (SCV) form of Staphylococcus aureus , as associated with the amount of capsule the bacteria produce. In this study we isolated… read more here.

Keywords: triclosan resistant; less capsule; small colony; staphylococcus aureus ... See more keywords

Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00621-22

Abstract: Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn… read more here.

Keywords: small colony; mutation; aminoglycoside resistance; pseudomonas aeruginosa ... See more keywords

In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics

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recommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.02532-17

Abstract: ABSTRACT The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable… read more here.

Keywords: staphylococcus aureus; lactam non; aureus small; lactam antibiotics ... See more keywords

Acute Infection with a Tobramycin-Induced Small Colony Variant of Staphylococcus aureus Causes Increased Inflammation in the Cystic Fibrosis Rat Lung

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recommendations! Published in 2022 at "Infection and Immunity"

DOI: 10.1128/iai.00237-22

Abstract: Cystic fibrosis (CF) disease is characterized by lifelong infections with pathogens such as Staphylococcus aureus, leading to eventual respiratory failure. Small colony variants (SCVs) of S. aureus have been linked to worse clinical outcomes for… read more here.

Keywords: tobramycin; staphylococcus aureus; small colony; colony ... See more keywords

Small Colonies, Bigger Problems? New Evidence That Staphylococcus aureus Small Colony Variants Can Worsen Lung Inflammation in Cystic Fibrosis Rats

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recommendations! Published in 2022 at "Infection and Immunity"

DOI: 10.1128/iai.00413-22

Abstract: Staphylococcus aureus is the most prevalent cystic fibrosis (CF) pathogen. During chronic airway infections, S. aureus adaptation to antibiotics includes evolving small colony variants (SCVs). ABSTRACT Staphylococcus aureus is the most prevalent cystic fibrosis (CF)… read more here.

Keywords: colony variants; staphylococcus aureus; small colony; colony ... See more keywords