Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-021-06045-w
Abstract: Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the… read more here.
Keywords: channel; activated potassium; conductance calcium; activity ... See more keywords
Melatonin Improves Memory Deficits in Rats with Cerebral Hypoperfusion, Possibly, Through Decreasing the Expression of Small-Conductance Ca2+-Activated K+ Channels
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02820-6
Abstract: This study investigated the expression pattern, regulation of expression, and the role of hippocampal small-conductance Ca2+-activated K+ (SK) channels in memory deficits after cerebral hypoperfusion (CHP) with or without melatonin treatment, in rats. Adults male… read more here.
Keywords: small conductance; expression; conductance ca2; memory deficits ... See more keywords
Functional Regulation of Small Conductance Calcium Activated Potassium Channel on Atrial Myocytes by Hydrogen Sulfide in Diabetes Mellitus
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DOI: 10.1016/j.bpj.2016.11.2274
Abstract: Previous studies established an essential role for Small Conductance Calcium Activated Potassium(SK) channels in cardiac dysrhythmias, especial in atrial dysrhythmias. Hydrogen sulfide (H2S), an endogenously generated gaseous transmitter, has recently been suggested to regulate cardiovascular… read more here.
Keywords: activated potassium; small conductance; channel; conductance calcium ... See more keywords
Small conductance Ca2+-activated K+ channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.05.005
Abstract: Ca2+-activated K+ (KCa) channels regulate after-hyperpolarization in many types of neurons in the central and peripheral nervous system. Small conductance Ca2+-activated K+ (KCa2/SK) channels, a subfamily of KCa channels, are widely expressed in the nervous… read more here.
Keywords: small conductance; ca2 activated; pharmacology; conductance ca2 ... See more keywords
Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis
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DOI: 10.1177/00368504211043763
Abstract: Numerous studies have demonstrated that anesthetics’ exposure to neonates imposes toxicity on the developing brain but the underlying mechanisms need to be further elucidated. Our present study aimed to explore the role of small conductance… read more here.
Keywords: activated potassium; small conductance; channel; ca2 activated ... See more keywords
The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00716
Abstract: The natural flavone acacetin inhibits several voltage-gated potassium currents in atrial myocytes, and has anti-atrial fibrillation (AF) effect in experimental AF models. The present study investigates whether acacetin inhibits the Ca2+-activated potassium (KCa) currents, including… read more here.
Keywords: flavone acacetin; small conductance; conductance; acacetin ... See more keywords
The Inhibition of the Small-Conductance Ca2+-Activated Potassium Channels Decreases the Sinus Node Pacemaking during Beta-Adrenergic Activation
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DOI: 10.3390/ph15030313
Abstract: Sinus pacemaking is based on tight cooperation of intracellular Ca2+ handling and surface membrane ion channels. An important player of this synergistic crosstalk could be the small-conductance Ca2+-activated K+-channel (ISK) that could contribute to the… read more here.
Keywords: conductance ca2; small conductance; adrenergic activation; beta adrenergic ... See more keywords