Sequencing of Small DNA Fragments with Aggregated-Induced-Emission Molecule Labelled Nucleotides.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c00707
Abstract: Sequencing by synthesis is a significant method for high-throughput DNA sequencing. Herein, we synthesized terminal aggregated-induced-emission luminogen (AIEgen) labelled nucleotides (dNTPs-HCAP) that could serve as substrates for some polymerases and applied them into the sequencing… read more here.
Keywords: labelled nucleotides; dna; sequencing small; small dna ... See more keywords
Small DNA circles as bacterial topoisomerase I inhibitors
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DOI: 10.1039/c9ra02398d
Abstract: It is demonstrated that small DNA circles showed high inhibitory effect on the activity of bacterial topoisomerase I and the single-stranded regions associated with bending deformation are believed to be the crucial factor for trapping… read more here.
Keywords: circles bacterial; small dna; bacterial topoisomerase; dna circles ... See more keywords