Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV‐CATCHER): A customizable purification assay designed for small‐RNA biomarker identification and evaluation of circulating small‐EVs
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12110
Abstract: Abstract Circulating nucleic acids, encapsulated within small extracellular vesicles (EVs), provide a remote cellular snapshot of biomarkers derived from diseased tissues, however selective isolation is critical. Current laboratory‐based purification techniques rely on the physical properties… read more here.
Keywords: small rna; evs; purification assay; small evs ... See more keywords
Periodontal ligament cells derived small extracellular vesicles are involved in orthodontic tooth movement.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of orthodontics"
DOI: 10.1093/ejo/cjac041
Abstract: OBJECTIVES Small extracellular vesicles (EVs) from human periodontal ligament cells (hPDLCs) are closely associated with periodontal homeostasis. Far less is known about EVs association with orthodontic tooth movement (OTM). This study aimed to explore the… read more here.
Keywords: hpdlcs; otm; small evs; tooth movement ... See more keywords
Circadian regulation of protein cargo in extracellular vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abc9061
Abstract: The circadian clock controls many aspects of physiology, but it remains undescribed whether extracellular vesicles (EVs), including exosomes, involved in cell-cell communications between tissues are regulated in a circadian pattern. We demonstrate a 24-hour rhythmic… read more here.
Keywords: cell; extracellular vesicles; protein cargo; regulation ... See more keywords
Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade0293
Abstract: Innovative therapeutic strategies are urgently needed for Alzheimer’s disease (AD) due to the increasing size of the aging population and the lack of effective drug treatment. Here, we report the therapeutic effects of extracellular vesicles… read more here.
Keywords: pathology; alzheimer disease; small evs; secreted endogenous ... See more keywords
TNF-α Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/2988907
Abstract: Human menstrual blood-derived mesenchymal stem cells (MenSCs) and their secreted small extracellular vesicles (EVs) had been proven to relieve inflammation, tissue damage, and fibrosis in various organs. The microenvironment induced by inflammatory cytokines can promote… read more here.
Keywords: extracellular vesicles; tnf; mensc derived; small evs ... See more keywords
Urinary small extracellular vesicles derived CCL21 mRNA as biomarker linked with pathogenesis for diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-021-03030-x
Abstract: Background Diabetic nephropathy (DN) is a leading cause of renal failure, whereas the effective and early diagnostic biomarkers are still lacking. Methods Fourteen cytokines and chemokines mRNA were detected in urinary extracellular vesicles (EVs) from… read more here.
Keywords: urinary small; small evs; diabetic nephropathy; derived ccl21 ... See more keywords
Inter-neuronal signaling mediated by small extracellular vesicles: wireless communication?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1187300
Abstract: Conventional inter-neuronal communication conceptualizes the wired method of chemical synapses that physically connect pre-and post-synaptic neurons. In contrast, recent studies indicate that neurons also utilize synapse-independent, hence “wireless” broadcasting-type communications via small extracellular vesicles (EVs).… read more here.
Keywords: extracellular vesicles; communication; mediated small; small extracellular ... See more keywords
Maternal Th17/Treg Cytokines and Small Extracellular Vesicles in Plasma as Potential Biomarkers for Preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.71047
Abstract: Preeclampsia is one of the most serious pregnancy complications. It may be caused by immunological changes in the early placental microenvironment. The contents of small EVs may serve as biomarkers of pregnancy complications. Evidence suggests… read more here.
Keywords: th17 treg; small evs; treg cytokines;
Novel Protocols for Scalable Production of High Quality Purified Small Extracellular Vesicles from Bovine Milk
Sign Up to like & getrecommendations! Published in 2021 at "Nanotheranostics"
DOI: 10.7150/ntno.62213
Abstract: Extracellular Vesicles (EVs) are cell-secreted nanovesicles that have unique potential for encapsulating and targeting “difficult-to-drug” therapeutic cargos. Milk provides an enriched source of EVs, and of particular interest to the drug delivery field, small EVs.… read more here.
Keywords: milk; extracellular vesicles; production; bovine milk ... See more keywords