Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Oncology"
DOI: 10.1002/1878-0261.70086
Abstract: Early diagnosis of colorectal cancer (CRC) is crucial for successful treatment and mortality reduction. In this regard, blood‐based tests play an indispensable role. Current research is focused on molecules actively secreted by tumor cells into… read more here.
Keywords: colorectal cancer; extracellular vesicles; cancer; extensive validation ... See more keywords
Melatonin‐Primed Mesenchymal Stem Cells‐Derived Small Extracellular Vesicles Alleviated Neurogenic Erectile Dysfunction by Reversing Phenotypic Modulation
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203087
Abstract: Erectile dysfunction (ED) is an adverse side effect of pelvic surgery with no effective treatment. In this study, it is explored whether melatonin could improve the therapeutic effects of small extracellular vesicles (sEVs), derived from… read more here.
Keywords: extracellular vesicles; modulation; erectile dysfunction; phenotypic modulation ... See more keywords
Recent Advances in Microfluidics for Nucleic Acid Analysis of Small Extracellular Vesicles in Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202401295
Abstract: Small extracellular vesicles (sEVs) are membranous vesicles released from cellular structures through plasma membrane budding. These vesicles contain cellular components such as proteins, lipids, mRNAs, microRNAs, long‐noncoding RNA, circular RNA, and double‐stranded DNA, originating from… read more here.
Keywords: extracellular vesicles; nucleic acid; cancer; advances microfluidics ... See more keywords
Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal‐Phenolic Networks
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202405188
Abstract: Small extracellular vesicles (sEVs) are cell‐derived particles used for intercellular communication in living organisms that have gained great interest from researchers for their use as drug carriers and diagnostic agents. However, the isolation and storage… read more here.
Keywords: extracellular vesicles; selectively disassemblable; metal phenolic; phenolic networks ... See more keywords
Bladder Cancer‐Derived Small Extracellular Vesicles Promote Tumor Angiogenesis by Inducing HBP‐Related Metabolic Reprogramming and SerRS O‐GlcNAcylation in Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202993
Abstract: A malformed tumour vascular network provokes the nutrient‐deprived tumour microenvironment (TME), which conversely activates endothelial cell (EC) functions and stimulates neovascularization. Emerging evidence suggests that the flexible metabolic adaptability of tumour cells helps to establish… read more here.
Keywords: extracellular vesicles; serrs glcnacylation; bladder cancer; small extracellular ... See more keywords
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202404822
Abstract: Small extracellular vesicles (sEVs) contain abundant circular RNAs (circRNAs) and are involved in cellular processes, particularly hypoxia. However, the process that packaging of circRNAs into neuronal sEVs under hypoxia is unclear. This study revealed the… read more here.
Keywords: extracellular vesicles; hypoxia; fus; small extracellular ... See more keywords
Isolation and Comprehensive Analysis of Cochlear Tissue‐Derived Small Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202408964
Abstract: Small extracellular vesicles (sEVs) act as a critical mediator in intercellular communication. Compared to sEVs derived from in vitro sources, tissue‐derived sEVs can reflect the in vivo signals released from specific tissues more accurately. Currently,… read more here.
Keywords: extracellular vesicles; analysis; small extracellular; cochlear tissue ... See more keywords
Phosphatidylcholine in bile-derived small extracellular vesicles as a novel biomarker of cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5973
Abstract: BACKGROUND Owing to the lack of definite diagnostic modalities, it is challenging to distinguish malignant cases of cholangiocarcinoma (CCA), which often causes biliary tract obstruction, from benign ones. Here, we investigated a novel lipid biomarker… read more here.
Keywords: extracellular vesicles; cca; small extracellular; derived small ... See more keywords
Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone‐Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.70031
Abstract: Small extracellular vesicles (SEVs) are membrane‐bound vesicles secreted by cells that facilitate intercellular communication. This study reveals how heat shock transcription factor 4 (HSF4) deficiency regulates SEV secretion in lens epithelial cells through chaperone‐mediated autophagy… read more here.
Keywords: extracellular vesicles; hsf4; small extracellular; secretion ... See more keywords
Atrophic skeletal muscle fibre‐derived small extracellular vesicle miR‐690 inhibits satellite cell differentiation during ageing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13106
Abstract: Sarcopenia is a common and progressive skeletal muscle disorder characterized by atrophic muscle fibres and contractile dysfunction. Accumulating evidence shows that the number and function of satellite cells (SCs) decline and become impaired during ageing,… read more here.
Keywords: muscle; satellite cell; muscle fibres; atrophic skeletal ... See more keywords
Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS‐CoV‐2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12179
Abstract: Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) entry is mediated by the interaction of the viral spike (S) protein with angiotensin‐converting enzyme 2 (ACE2) on the host cell surface. Although a clinical trial testing… read more here.
Keywords: sars cov; extracellular vesicles; infection; small extracellular ... See more keywords