Small Glycols Discover Cryptic Pockets on Proteins for Fragment-Based Approaches
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DOI: 10.1021/acs.jcim.0c01126
Abstract: Cryptic pockets are visible in ligand-bound protein structures but are occluded in unbound structures. Utilizing these pockets in fragment-based drug-design provides an attractive option for proteins not tractable by classical binding sites. However, owing to… read more here.
Keywords: fragment based; small glycols; cryptic pocket; pocket ... See more keywords