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   Articles with "small gtpase" as a keyword



In vitro reconstitution of small GTPase regulation

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14540

Abstract: Small GTPases play essential roles in the organization of eukaryotic cells. In recent years, it has become clear that their intracellular functions result from intricate biochemical networks of the GTPase and their regulators that dynamically… read more here.

Keywords: vitro reconstitution; small gtpase; gtpase; reconstitution small ... See more keywords
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Molecular principles of bidirectional signalling between membranes and small GTPases

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recommendations! Published in 2023 at "FEBS Letters"

DOI: 10.1002/1873-3468.14585

Abstract: Most small GTPases actuate their functions on subcellular membranes, which are increasingly seen as integral components of small GTPase signalling. In this review, we used the highly studied regulation of Arf GTPases by their GEFs… read more here.

Keywords: small gtpases; principles bidirectional; signalling membranes; molecular principles ... See more keywords

The small GTPase Sar1, control centre of COPII trafficking

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recommendations! Published in 2023 at "FEBS Letters"

DOI: 10.1002/1873-3468.14595

Abstract: Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates with the endoplasmic reticulum (ER) membrane and recruits COPII components, orchestrating cargo concentration and membrane deformation. Many aspects… read more here.

Keywords: gtpase sar1; sar1; sar1 control; centre copii ... See more keywords
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ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.12.122

Abstract: Small GTPase Rab17 has been shown to regulate a wide range of physiological processes including cell migration in tumor cells and dendrite morphogenesis in neurons. However, molecular mechanism underlying Rab17-mediated intracellular trafficking is still unclear.… read more here.

Keywords: rab17; rab17 interacting; rab17 associated; small gtpase ... See more keywords

Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c05781

Abstract: The small GTPase superfamily of proteins are crucial for numerous cellular processes, including early development. The roles of these proteins in osteogenic differentiation, however, remained poorly explored. In this study, we employed a high-throughput targeted… read more here.

Keywords: small gtpases; proteomic profiling; small gtpase; osteogenic differentiation ... See more keywords

Regulation of the small GTPase Rab1 function by a bacterial glucosyltransferase

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recommendations! Published in 2018 at "Cell Discovery"

DOI: 10.1038/s41421-018-0055-9

Abstract: Posttranslational modification of key host proteins by virulence factors is an important theme in bacterial pathogenesis. A remarkable example is the reversible modifications of the small GTPase Rab1 by multiple effectors of the bacterial pathogen… read more here.

Keywords: glucosyltransferase; rab1; small gtpase; gtpase ... See more keywords

The small GTPase MRAS is a broken switch

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-55967-y

Abstract: Intense research on founding members of the RAS superfamily has defined our understanding of these critical signalling proteins, leading to the premise that small GTPases function as molecular switches dependent on differential nucleotide loading. The… read more here.

Keywords: broken switch; small gtpase; mras broken; gtpase ... See more keywords

Small GTPase-dependent regulation of leukocyte-endothelial interactions in inflammation.

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recommendations! Published in 2018 at "Biochemical Society transactions"

DOI: 10.1042/bst20170530

Abstract: Inflammation is a complex biological response that serves to protect the body's tissues following harmful stimuli such as infection, irritation or injury and initiates tissue repair. At the start of an inflammatory response, pro-inflammatory mediators… read more here.

Keywords: response; adhesion; gtpase dependent; dependent regulation ... See more keywords

Extracellular vesicle formation in Euryarchaeota is driven by a small GTPase

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2311321121

Abstract: Significance Extracellular vesicles (EVs) play important roles in intercellular communication by transferring proteins, nucleic acids, lipids, and metabolites between cells. Few studies have investigated their role in Archaea. Here, we show that EVs of halophilic… read more here.

Keywords: vesicle formation; driven small; small gtpase; formation ... See more keywords

Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA

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recommendations! Published in 2017 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e16-06-0467

Abstract: Different forms of nuclear envelope–spanning LINC complexes have opposing roles in the transcription-independent control of the small GTPase RhoA. Competition between LINC complexes in the nuclear envelope may therefore dictate the outcome of signaling to… read more here.

Keywords: linc complexes; opposing roles; gtpase rhoa; small gtpase ... See more keywords

The small GTPase Rhb1 is involved in the cell response to fluconazole in Candida albicans

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recommendations! Published in 2019 at "FEMS Yeast Research"

DOI: 10.1093/femsyr/foz005

Abstract: Abstract Candida albicans is an important fungal pathogen in humans. Rhb1 is a small GTPase of the Ras superfamily and is conserved from yeasts to humans. In C. albicans, Rhb1 regulates the expression of secreted… read more here.

Keywords: response fluconazole; candida albicans; rhb1; small gtpase ... See more keywords