In vitro reconstitution of small GTPase regulation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14540
Abstract: Small GTPases play essential roles in the organization of eukaryotic cells. In recent years, it has become clear that their intracellular functions result from intricate biochemical networks of the GTPase and their regulators that dynamically… read more here.
Keywords: vitro reconstitution; small gtpase; gtpase; reconstitution small ... See more keywords
Molecular principles of bidirectional signalling between membranes and small GTPases
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14585
Abstract: Most small GTPases actuate their functions on subcellular membranes, which are increasingly seen as integral components of small GTPase signalling. In this review, we used the highly studied regulation of Arf GTPases by their GEFs… read more here.
Keywords: small gtpases; principles bidirectional; signalling membranes; molecular principles ... See more keywords
The small GTPase Sar1, control centre of COPII trafficking
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14595
Abstract: Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates with the endoplasmic reticulum (ER) membrane and recruits COPII components, orchestrating cargo concentration and membrane deformation. Many aspects… read more here.
Keywords: gtpase sar1; sar1; sar1 control; centre copii ... See more keywords
ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.122
Abstract: Small GTPase Rab17 has been shown to regulate a wide range of physiological processes including cell migration in tumor cells and dendrite morphogenesis in neurons. However, molecular mechanism underlying Rab17-mediated intracellular trafficking is still unclear.… read more here.
Keywords: rab17; rab17 interacting; rab17 associated; small gtpase ... See more keywords
Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05781
Abstract: The small GTPase superfamily of proteins are crucial for numerous cellular processes, including early development. The roles of these proteins in osteogenic differentiation, however, remained poorly explored. In this study, we employed a high-throughput targeted… read more here.
Keywords: small gtpases; proteomic profiling; small gtpase; osteogenic differentiation ... See more keywords
Regulation of the small GTPase Rab1 function by a bacterial glucosyltransferase
Sign Up to like & getrecommendations! Published in 2018 at "Cell Discovery"
DOI: 10.1038/s41421-018-0055-9
Abstract: Posttranslational modification of key host proteins by virulence factors is an important theme in bacterial pathogenesis. A remarkable example is the reversible modifications of the small GTPase Rab1 by multiple effectors of the bacterial pathogen… read more here.
Keywords: glucosyltransferase; rab1; small gtpase; gtpase ... See more keywords
Small GTPase-dependent regulation of leukocyte-endothelial interactions in inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20170530
Abstract: Inflammation is a complex biological response that serves to protect the body's tissues following harmful stimuli such as infection, irritation or injury and initiates tissue repair. At the start of an inflammatory response, pro-inflammatory mediators… read more here.
Keywords: response; adhesion; gtpase dependent; dependent regulation ... See more keywords
Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-06-0467
Abstract: Different forms of nuclear envelope–spanning LINC complexes have opposing roles in the transcription-independent control of the small GTPase RhoA. Competition between LINC complexes in the nuclear envelope may therefore dictate the outcome of signaling to… read more here.
Keywords: linc complexes; opposing roles; gtpase rhoa; small gtpase ... See more keywords
The small GTPase Rhb1 is involved in the cell response to fluconazole in Candida albicans
Sign Up to like & getrecommendations! Published in 2019 at "FEMS Yeast Research"
DOI: 10.1093/femsyr/foz005
Abstract: Abstract Candida albicans is an important fungal pathogen in humans. Rhb1 is a small GTPase of the Ras superfamily and is conserved from yeasts to humans. In C. albicans, Rhb1 regulates the expression of secreted… read more here.
Keywords: response fluconazole; candida albicans; rhb1; small gtpase ... See more keywords
A rice small GTPase, Rab6a, is involved in the regulation of grain yield and iron nutrition in response to CO2 enrichment
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/eraa279
Abstract: Abstract Despite extensive studies on the effects of elevated atmospheric CO2 concentrations ([CO2]) on rice, the molecular mechanisms and signaling events underlying the adaptation of plants remain largely elusive. Here, we report that OsRab6a, which… read more here.
Keywords: grain yield; involved regulation; rice; co2 ... See more keywords
OS12.5 Small GTPase RHOE/RND3, a new critical regulator of NF-êB signaling in glioblastoma multiforme?
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.077
Abstract: Abnormal activation of NF-κB signaling is a major mechanism of apoptosis resistance in glioblastoma multiforme (GBM). Therefore, better understanding of the regulation of NF-κB signaling has a significant impact for GBM therapy. Here, we uncovered… read more here.
Keywords: apoptosis; gbm; glioblastoma multiforme; small gtpase ... See more keywords