Molecular principles of bidirectional signalling between membranes and small GTPases
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14585
Abstract: Most small GTPases actuate their functions on subcellular membranes, which are increasingly seen as integral components of small GTPase signalling. In this review, we used the highly studied regulation of Arf GTPases by their GEFs… read more here.
Keywords: small gtpases; principles bidirectional; signalling membranes; molecular principles ... See more keywords
The role of small GTPases of the Rho/Rac family in TGF‐β‐induced EMT and cell motility in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24505
Abstract: This article focuses on the role of Rho family GTPases, particularly Rac1 and Rac1b in TGF‐β‐induced epithelial‐mesenchymal transition (EMT) and EMT‐associated responses such as cell migration, invasion, and metastasis in cancer. EMT is considered a… read more here.
Keywords: family; small gtpases; tgf; role ... See more keywords
Biochemical Assays to Detect Activation of Small GTPases Rho, Rac, and Cdc42 during Morphogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2035-9_5
Abstract: Wnt/Frizzled (Fz) signaling controls developmental, physiological, and pathological processes through several distinct pathways. Wnt/Fz activation of the small GTPases Rho, Rac, and Cdc42, is one key mechanism that regulates cell polarity and migration during vertebrate… read more here.
Keywords: activation small; rac cdc42; small gtpases; rho rac ... See more keywords
Self-assemblies of Rab- and Arf-family small GTPases on lipid bilayers in membrane tethering.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical reviews"
DOI: 10.1007/s12551-021-00819-4
Abstract: Small GTPases of the Ras superfamily, which include Ras-, Rho-, Rab-, Arf-, and Ran-family isoforms, are generally known to function as a nucleotide-dependent molecular switch in eukaryotic cells. In the GTP-loaded forms, they selectively recruit… read more here.
Keywords: rab arf; small gtpases; self assemblies; membrane tethering ... See more keywords
Targeted Proteomic Analysis of Small GTPases in Radioresistant Breast Cancer Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02389
Abstract: Radiation therapy benefits more than 50% of all cancer patients and cures 40% of them, where ionizing radiation (IR) deposits energy to cells and tissues, thereby eliciting DNA damage and resulting in cell death. Small… read more here.
Keywords: small gtpases; cancer; breast cancer; cancer cells ... See more keywords
Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05781
Abstract: The small GTPase superfamily of proteins are crucial for numerous cellular processes, including early development. The roles of these proteins in osteogenic differentiation, however, remained poorly explored. In this study, we employed a high-throughput targeted… read more here.
Keywords: small gtpases; proteomic profiling; small gtpase; osteogenic differentiation ... See more keywords
Functional diversity in the RAS subfamily of small GTPases.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20211166
Abstract: RAS small GTPases regulate important signalling pathways and are notorious drivers of cancer development and progression. While most research to date has focused on understanding and addressing the oncogenic potential of three RAS oncogenes: HRAS,… read more here.
Keywords: small gtpases; ras subfamily; subfamily small; functional diversity ... See more keywords
EXTH-64. SMALL GTPASES IN MENINGIOMAS: PROLIFERATION, MIGRATION, SURVIVAL, POTENTIAL TREATMENT AND INTERACTIONS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.418
Abstract: To evaluate the role of the small GTPases RhoA, Rac1 and Cdc42 in meningiomas as therapeutic targets and their interactions in meningiomas. We analyzed expression of GTPases in human meningioma samples and meningioma cell lines… read more here.
Keywords: proliferation migration; treatment; proliferation; small gtpases ... See more keywords
The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000489917
Abstract: Background/Aims: The epigenetic factor KDM2B is a histone demethylase expressed in various tumors. Recently, we have shown that KDM2B regulates actin cytoskeleton organization, small Rho GTPases signaling, cell-cell adhesion and migration of prostate tumor cells.… read more here.
Keywords: tumor cells; colon tumor; small gtpases; kdm2b ... See more keywords
HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.1a0416-195r
Abstract: Neutrophil extravasation is a critical step of the innate immune system's response to inflammation. This multistep process is tightly regulated by adhesion and signaling molecules in the endothelium and neutrophils. Activation of the β2 integrin… read more here.
Keywords: vivo; activation small; adhesion; small gtpases ... See more keywords
The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function
Sign Up to like & getrecommendations! Published in 2017 at "Biological Chemistry"
DOI: 10.1515/hsz-2016-0276
Abstract: Abstract Ras GTPases are key players in cellular signalling because they act as binary switches. These states manifest through toggling between an active (GTP-loaded) and an inactive (GDP-loaded) form. The hydrolysis and replenishing of GTP… read more here.
Keywords: small gtpases; multidimensional nmr; structure function; spectroscopy ... See more keywords