Targeted Dual Small Interfering Ribonucleic Acid Delivery via Non-Viral Polymeric Vectors for Pulmonary Fibrosis Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202007798
Abstract: Inhibiting the myofibroblast differentiation of lung-resident mesenchymal stem cells (LR-MSCs) is a promising yet challenging approach for pulmonary fibrosis (PF) therapy. Here, micelles formed by a graft copolymer of multiple PEGs modified branched polyethylenimine are… read more here.
Keywords: myofibroblast differentiation; fibrosis therapy; small interfering; pulmonary fibrosis ... See more keywords
Enhancing WRAP‐Based Nanoparticles for Small Interfering Ribonucleic Acid Delivery in pH‐Sensitive Environments
Sign Up to like & getrecommendations! Published in 2025 at "Chemmedchem"
DOI: 10.1002/cmdc.202400885
Abstract: Small interfering RNAs (siRNA) are promising therapeutic molecules that require delivery systems to reach their targets. Several siRNA delivery systems, such as lipid‐ or peptide‐based nanoparticles, are developed for different pathologies. In this context, we… read more here.
Keywords: based nanoparticles; small interfering; delivery; wrap based ... See more keywords
Inhibition of dengue virus infection by small interfering RNAs that target highly conserved sequences in the NS4B or NS5 coding regions
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3757-2
Abstract: Dengue fever is one of the most common viral infections in the world. Although a vaccine against dengue virus (DENV) has been approved in several countries, this disease is still considered a public health priority… read more here.
Keywords: dengue virus; small interfering; sequences ns4b; conserved sequences ... See more keywords
Computational Identification of Small Interfering RNA Targets in SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Virologica Sinica"
DOI: 10.1007/s12250-020-00221-6
Abstract: With the epidemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) worldwide and in the absence of any effective vaccine, there is an urgent need to find a specific anti- SARS-CoV-2 agent. In this study,… read more here.
Keywords: small interfering; identification small; interfering rna; rna targets ... See more keywords
Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.05.034
Abstract: Nogo-B receptor (NgBR) plays fundamental roles in regulating angiogenesis, vascular development, and the epithelial-mesenchymal transition (EMT) of cancer cells. However, the therapeutic effect of NgBR blockade on tumor vasculature and malignancy is unknown, investigations on… read more here.
Keywords: ngbr; nogo receptor; delivery; small interfering ... See more keywords
Promising approaches of small interfering RNAs (siRNAs) mediated cancer gene therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144071
Abstract: RNA interference (RNAi) has extensive potential to revolutionize every aspect of clinical application in biomedical research. One of the promising tools is the Small interfering RNA (siRNA) molecules within a cellular component. Principally, siRNA mediated… read more here.
Keywords: therapy; mediated cancer; small interfering; cancer gene ... See more keywords
Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions
Sign Up to like & getrecommendations! Published in 2018 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2018.04.004
Abstract: Abstract RNA silencing is a novel gene regulatory mechanism that confines the transcript level by either preventing translation or by the initiation of particular RNA degradation. Small interfering RNAs are regularly represented as the exogenously… read more here.
Keywords: small interfering; p53 gene; small hairpin; interfering rnas ... See more keywords
The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis
Sign Up to like & getrecommendations! Published in 2017 at "JACC: Basic to Translational Science"
DOI: 10.1016/j.jacbts.2017.03.005
Abstract: Central Illustration ALK1 Mediates LDL Uptake and Transcytosis in Endothelial Cells (A) Genome-wide ribonucleic acid interference screen targeting over 18,000 genes in cultured endothelial cells (ECs), and publicly available genome wide association studies (GWAS) reveal… read more here.
Keywords: genome wide; association studies; ribonucleic acid; small interfering ... See more keywords
Organometallic dendrimers based on Ruthenium(II) N-heterocyclic carbenes and their implication as delivery systems of anticancer small interfering RNA.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111540
Abstract: With the purpose of obtaining a new dendritic system against cancer, this paper is focused on the synthesis of spherical carbosilane metallodendrimers of different generations holding Ru(II) N-heterocyclic carbene (NHC) on the periphery from the… read more here.
Keywords: anticancer small; ruthenium; organometallic dendrimers; small interfering ... See more keywords
Small interfering RNAs (siRNAs) based gene silencing strategies for the treatment of glaucoma: Recent advancements and future perspectives.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118712
Abstract: RNA-interference-based mechanisms, especially the use of small interfering RNAs (siRNAs), have been under investigation for the treatment of several ailments and have shown promising results for ocular diseases including glaucoma. The eye, being a confined… read more here.
Keywords: sirna based; treatment; small interfering; glaucoma ... See more keywords
From current knowledge to best practice: A primer on Viral diagnostics using deep sequencing of virus-derived small interfering RNAs (vsiRNAs) in infected plants.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.10.009
Abstract: Plants have evolved many defense strategies for combating viral infections. One major surveillance strategy adopted by them is manipulating viral sequences to generate distinct small RNA products via Dicer-like enzymes (DCL), and thereby restricting virus… read more here.
Keywords: virus derived; using deep; derived small; small interfering ... See more keywords