Self‐Assembly of Naturally Small Molecules into Supramolecular Fibrillar Networks for Wound Healing
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102476
Abstract: Self‐assemblies of bioactively natural compounds into supramolecular hydrogels without structural modifications are of interest to improve their sustained releases and bioavailabilities in vivo. However, it is still a formidable challenge to dig out such a… read more here.
Keywords: wound healing; self assembly; hydrogel; naturally small ... See more keywords
In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201906022
Abstract: Approaches that enable innate repair mechanisms hold great potential for tissue repair. Herein, biomaterial-assisted sequestration of small molecules is described to localize pro-regenerative signaling at the injury site. Specifically, a synthetic biomaterial containing boronate molecules… read more here.
Keywords: sequestration; small molecules; sequestration innate; adenosine ... See more keywords
Recent Development of Quinoxaline Based Polymers/Small Molecules for Organic Photovoltaics
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Energy Materials"
DOI: 10.1002/aenm.201700575
Abstract: Among the various molecular designs developed for the synthesis of conjugated polymers and small molecules for optoelectronic applications, the donor: acceptor (D-A) approach is the most widely explored method over the past decades. Through the… read more here.
Keywords: small molecules; quinoxaline based; polymers small; based polymers ... See more keywords
microRNAs: small molecules with a large impact on colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2255
Abstract: Colorectal cancer (CRC) accounts for one of the main cancer related mortality and morbidity worldwide. The molecular mechanisms of CRC development have been broadly investigated and, over the last decade, it has become evident that… read more here.
Keywords: molecules large; large impact; colorectal cancer; small molecules ... See more keywords
Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling
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DOI: 10.1002/cbic.201700260
Abstract: Wnt signaling is a fundamental pathway that drives embryonic development and is essential for stem cell maintenance and tissue homeostasis. Dysregulation of Wnt signaling is linked to various diseases, and a constitutively active Wnt pathway… read more here.
Keywords: wnt signaling; small molecules; inhibitors wnt; natural product ... See more keywords
Se⋅⋅⋅O/S and S⋅⋅⋅O Chalcogen Bonds in Small Molecules and Proteins: A Combined CSD and PDB Study
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100498
Abstract: The importance of selenium‐centered noncovalent chalcogen bonds represented as Se⋅⋅⋅A (A=O/S) has been explored for short directional contacts in small molecules and proteins. In addition, S⋅⋅⋅O centered contacts have been analyzed. Computational analyses involving the… read more here.
Keywords: pdb; molecules proteins; chalcogen bonds; small molecules ... See more keywords
Endogenous Proteins Modulation in Live Cells with Small Molecules and Light
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DOI: 10.1002/cbic.202200244
Abstract: Protein modulation by light illumination enables the investigation of biological function in high spatiotemporal precision. Compared to genetic methods, the small molecule approach is uniquely suited for modulating endogenous proteins. Endogenous protein modulation in live… read more here.
Keywords: molecules light; endogenous proteins; live cells; small molecules ... See more keywords
New chiral stationary phases for liquid chromatography based on small molecules: Development, enantioresolution evaluation and chiral recognition mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Chirality"
DOI: 10.1002/chir.23142
Abstract: Recently, we reported the development of new chiral stationary phases (CSPs) for liquid chromatography (LC) based on chiral derivatives of xanthones (CDXs). Based on the most promising CDX selectors, 12 new CSPs were successfully prepared… read more here.
Keywords: small molecules; chromatography based; chiral stationary; liquid chromatography ... See more keywords
Chemical Space Overlap with Critical Protein–Protein Interface Residues in Commercial and Specialized Small‐Molecule Libraries
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DOI: 10.1002/cmdc.201800537
Abstract: There is growing interest in the use of structure‐based virtual screening to identify small molecules that inhibit challenging protein–protein interactions (PPIs). In this study, we investigated how effectively chemical library members docked at the PPI… read more here.
Keywords: interface; small molecule; small molecules; protein protein ... See more keywords
Recent developments in metalloporphyrin electrocatalysts for reduction of small molecules: strategies for managing electron and proton transfer reactions.
Sign Up to like & getrecommendations! Published in 2020 at "ChemSusChem"
DOI: 10.1002/cssc.202001914
Abstract: Porphyrins are archetypal ligands in inorganic chemistry. The last 10 years have seen important new advances in the use of metalloporphyrins as catalysts in the activation and reduction of small molecules, in particular O 2… read more here.
Keywords: reduction; reduction small; recent developments; small molecules ... See more keywords
Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin‐1 binding of small molecules
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21641
Abstract: Neuropilin‐1 (NRP1) is emerging as an important molecule in immune signaling where it has been shown to modulate the actions of TGF‐β1 in macrophages and regulatory T cells. The development of cost‐effective and reliable assays… read more here.
Keywords: novel fluorescent; small molecules; fluorescent chemical; probe suitable ... See more keywords