Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice.
Sign Up to like & getrecommendations! Published in 2021 at "Mitochondrion"
DOI: 10.1016/j.mito.2021.02.007
Abstract: Type 2 Diabetes mellitus (T2DM) has become a major public health issue associated with a high risk of late-onset Alzheimer's disease (LOAD). Mitochondrial dysfunction is one of the molecular events that occur in the LOAD… read more here.
Keywords: peptide ss31; mitochondria targeted; targeted small; mice ... See more keywords
Stereoselective Access to Azetidine-Based α-Amino Acids and Applications to Small Peptide Synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03131
Abstract: Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asymmetric reduction allowed for the synthesis of a new library of… read more here.
Keywords: amino acids; azetidine based; stereoselective access; small peptide ... See more keywords
Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1–RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01927-x
Abstract: P21 Activated Kinase 1 (PAK1) is an oncogenic serine/threonine kinase known to play a significant role in the regulation of cytoskeleton and cell morphology. Runt-related transcription factor 3 (RUNX3) was initially known for its tumor… read more here.
Keywords: phosphorylation; threonine 209; runx3; small peptide ... See more keywords
Geometrical optimisation of a personalised microneedle eye patch for transdermal delivery of anti-wrinkle small peptide.
Sign Up to like & getrecommendations! Published in 2020 at "Biofabrication"
DOI: 10.1088/1758-5090/ab6d37
Abstract: Acetyl-hexapeptide 3 (AHP-3) is a small peptide with good anti-wrinkle efficacy and safety profile. However, due to its hydrophilicity and high molecular weight, its skin permeation is generally poor. Innovative microneedle (MN) patch such as… read more here.
Keywords: transdermal delivery; anti wrinkle; patch; geometry ... See more keywords
A Computational Investigation of Small Peptide of Methyl Jasmonate and Human Complement Factor in Ageing
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Genomics"
DOI: 10.1155/ijog/9783996
Abstract: Background Ageing contributes to the onset of various diseases. It is accompanied by malfunctioning and deterioration of the body systems. Identifying the biomarkers for the prediction, diagnosis, management, or prognosis of ageing and biological ageing… read more here.
Keywords: small peptide; peptide methyl; mje1; methyl jasmonate ... See more keywords
Discovery and Characterization of a High-Affinity Small Peptide Ligand, H1, Targeting FGFR2IIIc for Skin Wound Healing
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000493287
Abstract: Background/Aims: How to aid recovery from severe skin injuries, such as burns, chronic or radiation ulcers, and trauma, is a critical clinical problem. Current treatment methods remain limited, and the discovery of ideal wound-healing therapeutics… read more here.
Keywords: wound healing; peptide; affinity; skin wound ... See more keywords
Small peptide CSF fingerprint of amyotrophic lateral sclerosis.
Sign Up to like & getrecommendations! Published in 2024 at "PloS one"
DOI: 10.1371/journal.pone.0302280
Abstract: BACKGROUND Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by abnormal protein aggregation in the motor neurons. Present and earlier proteomic studies to characterize peptides in cerebrospinal fluid (CSF) associated with motoneuron pathology did… read more here.
Keywords: small peptide; protein; csf; amyotrophic lateral ... See more keywords
Effects of Small Peptide Supplementation on Growth Performance, Intestinal Barrier of Laying Hens During the Brooding and Growing Periods
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.925256
Abstract: The growing period is a critical period for growth and development in laying hens. During this period, chicks grow rapidly, but are accompanied by unstable digestive function, incomplete organ development, and high mortality. Small peptide,… read more here.
Keywords: effects small; supplementation; growth; laying hens ... See more keywords
In Vivo Characterization of ONL1204, a Small Peptide Inhibitor of the Fas Receptor, as a Potential Neuroprotective Therapy for Geographic Atrophy and Dry Age-Related Macular Degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Biomedicines"
DOI: 10.3390/biomedicines13092052
Abstract: Background: Age-related macular degeneration (AMD) is a major cause of irreversible vision loss in the developed world, and the approved products for geographic atrophy (GA), a late-stage form of dry AMD, have shown limited efficacy… read more here.
Keywords: small peptide; geographic atrophy; related macular; onl1204 small ... See more keywords
Optimisation of a Microfluidic Method for the Delivery of a Small Peptide
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13091505
Abstract: Peptides hold promise as therapeutics, as they have high bioactivity and specificity, good aqueous solubility, and low toxicity. However, they typically suffer from short circulation half-lives in the body. To address this issue, here, we… read more here.
Keywords: microscopy; method delivery; microfluidic method; optimisation microfluidic ... See more keywords