Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands.
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DOI: 10.1016/j.ceb.2019.12.005
Abstract: Key metabolites act through specific G protein-coupled receptors (GPCRs) as extracellular signals of fuel availability and metabolic stress. Here, we focus on the succinate receptor SUCNR1/GPR91 and the long chain fatty acid receptor FFAR1/GPR40, for… read more here.
Keywords: structural basis; basis gpcr; signaling small; small polar ... See more keywords