Interacting partners of Golgi‐localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP‐Trap pull down
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14443
Abstract: The small G protein Arl5b is localised on the trans‐Golgi network (TGN) and regulates endosomes‐to‐TGN transport. Here, we combined in vivo and in vitro techniques to map the interactive partners and near neighbours of Arl5b at the… read more here.
Keywords: small protein; proximity labelling; arl5b; gfp trap ... See more keywords
Reconstitution of an Anti‐HER2 Antibody Paratope by Grafting Dual CDR‐Derived Peptides onto a Small Protein Scaffold
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Journal"
DOI: 10.1002/biot.202000078
Abstract: Target‐binding small proteins are promising alternatives to conventional monoclonal antibodies (mAbs), offering advantages in terms of tissue penetration and manufacturing costs. Recently, a design strategy to create small proteins called fluctuation‐regulated affinity proteins (FLAPs) consisting… read more here.
Keywords: protein scaffold; dual cdr; cdr derived; cdr ... See more keywords
Cytosolic Delivery of Small Protein Scaffolds Enables Efficient Inhibition of Ras and Myc.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00798
Abstract: The ability to deliver small protein scaffolds intracellularly could enable the targeting and inhibition of many therapeutic targets that are not currently amenable to inhibition with small-molecule drugs. Here, we report the engineering of small… read more here.
Keywords: small protein; cytosolic delivery; inhibition; protein scaffolds ... See more keywords
An uncharacterized small protein MicN mediates the transcriptional reprogramming of Salmonella through regulating the RpoS-RNA polymerase interaction
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08989-7
Abstract: Salmonella adapts its metabolism upon entry into macrophages to survive in the hostile host environment. However, the specific regulatory mechanisms involved remain largely unknown. In this study, we identify a previously uncharacterized small protein, MicN,… read more here.
Keywords: rna polymerase; salmonella; small protein; interaction ... See more keywords
Discovery of a small protein factor involved in the coordinated degradation of phycobilisomes in cyanobacteria
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2012277118
Abstract: Significance During genome analysis, genes encoding small proteins are frequently neglected. Accordingly, small proteins have remained underinvestigated in all domains of life. Based on a previous systematic search for such genes, we present the functional… read more here.
Keywords: nitrogen; degradation; nbld; factor ... See more keywords
RHOA, a small G-protein, signals to mitophagy through regulation of PINK1 protein stability and protects cardiomyocytes against ischemia.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2132707
Abstract: RHOA (ras homolog family member A) is a small G-protein that regulates a range of cellular processes including cell growth and survival. RHOA is a proximal downstream effector of G protein-coupled receptor coupling to GNA12/Gα12-GNA13/Gα13… read more here.
Keywords: small protein; protein stability; rhoa; protein ... See more keywords
Rewiring of cell morphology by Small protein B enhances stress tolerance and colonization in Aeromonas veronii under adverse conditions
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf608
Abstract: Abstract Pathogens often display morphological plasticity to withstand environmental stress and thrive in complex host immune environments. In this study, we demonstrated the morphological adaptation of Aeromonas veronii, a severe pathogen with a wide environmental… read more here.
Keywords: morphological adaptation; smpb; colonization; small protein ... See more keywords
Small G protein RAC‐2 regulates forgetting via the JNK‐1 signalling pathway in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15855
Abstract: Although forgetting was once regarded as a passive decline in memory and an occasional source of embarrassment, recent research suggests that it is an active biological process of removing outdated or irrelevant memories via activation… read more here.
Keywords: small protein; caenorhabditis elegans; rac; jnk ... See more keywords
The Small Protein SgrT Controls Transport Activity of the Glucose-Specific Phosphotransferase System
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bacteriology"
DOI: 10.1128/jb.00869-16
Abstract: ABSTRACT The bacterial small RNA (sRNA) SgrS has been a fruitful model for discovery of novel RNA-based regulatory mechanisms and new facets of bacterial physiology and metabolism. SgrS is one of only a few characterized… read more here.
Keywords: sgrt; activity; protein sgrt; transport activity ... See more keywords
Differential synthesis of novel small protein times Salmonella virulence program
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010074
Abstract: Gene organization in operons enables concerted transcription of functionally related genes and efficient control of cellular processes. Typically, an operon is transcribed as a polycistronic mRNA that is translated into corresponding proteins. Here, we identify… read more here.
Keywords: virulence; small protein; gene; virulence program ... See more keywords
A Hydrophobic Small Protein, BpOF4_01690, Is Critical for Alkaliphily of Alkaliphilic Bacillus pseudofirmus OF4
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01994
Abstract: A monocistronic small protein, BpOF4_01690, was annotated in alkaliphilic Bacillus pseudofirmus OF4. It comprises 59 amino acids and is hydrophobic. Importantly, homologs of this protein were identified only in alkaliphiles. In this study, a mutant… read more here.
Keywords: bacillus pseudofirmus; alkaliphilic bacillus; bpof4 01690; protein bpof4 ... See more keywords