Bayesian methods to compare dose levels with placebo in a small n, sequential, multiple assignment, randomized trial.
Sign Up to like & getrecommendations! Published in 2020 at "Statistics in medicine"
DOI: 10.1002/sim.8813
Abstract: Clinical trials studying treatments for rare diseases are challenging to design and conduct due to the limited number of patients eligible for the trial. One design used to address this challenge is the small n,… read more here.
Keywords: trial; multiple assignment; small sequential; treatment ... See more keywords
Power prior models for estimating response rates in a small n, sequential, multiple assignment, randomized trial
Sign Up to like & getrecommendations! Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802221122795
Abstract: A small n, sequential, multiple assignment, randomized trial (snSMART) is a small sample, two-stage design where participants receive up to two treatments sequentially, but the second treatment depends on response to the first treatment. The… read more here.
Keywords: response rates; power prior; small sequential; prior models ... See more keywords