Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.
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DOI: 10.1039/c6md00564k
Abstract: Small molecule DGAT2 inhibitors have shown promise for the treatment of metabolic diseases in preclinical models. Herein, we report the first toxicological evaluation of imidazopyridine-based DGAT2 inhibitors and show that the arteriopathy associated with imidazopyridine… read more here.
Keywords: structural changes; imidazopyridine diacylglycerol; dgat2 inhibitors; small structural ... See more keywords
Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants
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DOI: 10.3390/ijms22169087
Abstract: The SARS-CoV-2 pseudovirus is a commonly used strategy that mimics certain biological functions of the authentic virus by relying on biological legitimacy at the molecular level. Despite the fact that spike (S), envelope (E), and… read more here.
Keywords: structural proteins; cov pseudovirus; proteins render; infectivity ... See more keywords