Cox proportional hazards regression in small studies of predictive biomarkers
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-64573-9
Abstract: Predictive biomarkers are essential for personalized medicine since they select the best treatment for a specific patient. However, of all biomarkers that are evaluated, only few are eventually used in clinical practice. Many promising biomarkers… read more here.
Keywords: small studies; proportional hazards; cox model; cox proportional ... See more keywords
Key concepts for informed health choices. 2.4: descriptions of effects should reflect the risk of being misled by the play of chance
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DOI: 10.1177/01410768221140750
Abstract: When there are few outcome events, differences in outcome frequencies between the treatment comparison groups may easily have occurred by chance and may mistakenly be attributed to differences in the effects of the treatments, or… read more here.
Keywords: effect estimates; small studies; effect; risk ... See more keywords
Small studies in systematic reviews: To include or not to include?
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DOI: 10.12688/f1000research.127100.1
Abstract: Background: COVID-19 provided a real challenge for evidence synthesis due to the rapid growth of evidence. We aim to assess the impact of including all studies versus including larger studies only in systematic reviews when… read more here.
Keywords: small studies; systematic reviews; 000 patients; evidence ... See more keywords