LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "smallpox" as a keyword



Use of live Variola virus to determine whether CAST/EiJ mice are a suitable surrogate animal model for human smallpox.

Sign Up to like & get
recommendations! Published in 2019 at "Virus research"

DOI: 10.1016/j.virusres.2019.197772

Abstract: Numerous animal models of systemic orthopoxvirus disease have been developed to evaluate therapeutics against variola virus (VARV), the causative agent of smallpox. These animal models do not resemble the disease presentation in human smallpox and… read more here.

Keywords: smallpox; model; eij mice; cast eij ... See more keywords

A case of osteomyelitis variolosa from Roman Britain, and the introduction of smallpox to the Roman world

Sign Up to like & get
recommendations! Published in 2025 at "Journal of Roman Archaeology"

DOI: 10.1017/s1047759424000357

Abstract: Abstract This article presents a case of osteomyelitis variolosa from a skeleton excavated in the Western Cemetery at Cirencester (Corinium) in Britain, dated to the 3rd or 4th c. CE. This osteological condition is caused… read more here.

Keywords: smallpox; osteomyelitis variolosa; roman; case osteomyelitis ... See more keywords

Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential

Sign Up to like & get
recommendations! Published in 2023 at "Expert Review of Anti-infective Therapy"

DOI: 10.1080/14787210.2023.2170350

Abstract: ABSTRACT Introduction Tecovirimat oral capsule formulation is approved in the US and Canada for treatment of smallpox and in the United Kingdom (UK) and European Union (EU) for treatment of multiple human orthopoxvirus diseases, including… read more here.

Keywords: mpox; formulation; smallpox; development ... See more keywords

The De Novo Synthesis of Horsepox Virus: Implications for Biosecurity and Recommendations for Preventing the Reemergence of Smallpox.

Sign Up to like & get
recommendations! Published in 2017 at "Health security"

DOI: 10.1089/hs.2017.0061

Abstract: In March 2017, the American biotech company Tonix announced that a Canadian scientist had synthesized horsepox virus as part of a project to develop a safer vaccine against smallpox. The first de novo synthesis of… read more here.

Keywords: smallpox; horsepox; reemergence smallpox; virus ... See more keywords
Photo from wikipedia

Reevaluating the Risk of Smallpox Reemergence.

Sign Up to like & get
recommendations! Published in 2020 at "Military medicine"

DOI: 10.1093/milmed/usaa084

Abstract: INTRODUCTION Smallpox, caused by variola virus, was eradicated in 1980, but remains a category A bioterrorism agent. A decade ago, smallpox ranked second after anthrax in a multifactorial risk priority scoring analysis of category A… read more here.

Keywords: category bioterrorism; risk; synthetic biology; smallpox ... See more keywords

Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

Sign Up to like & get
recommendations! Published in 2021 at "mSphere"

DOI: 10.1128/msphere.00927-20

Abstract: Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Smallpox, caused by variola virus (VARV) infection, is highly transmissible, with an estimated 30%… read more here.

Keywords: highly transmissible; brincidofovir; model; monkeypox virus ... See more keywords
Photo from wikipedia

Edward Jenner’s 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox

Sign Up to like & get
recommendations! Published in 2018 at "Journal of the Royal Society of Medicine"

DOI: 10.1177/0141076818783658

Abstract: Variolation, that is, the inoculation of smallpox material in people who have not experienced natural smallpox, appears to have been a prophylactic used for centuries in much of Asia and North Africa. It was introduced… read more here.

Keywords: 1798 report; jenner 1798; smallpox; variolation ... See more keywords

Probabilistic thinking and evaluation of therapies: an introductory overview

Sign Up to like & get
recommendations! Published in 2020 at "Journal of the Royal Society of Medicine"

DOI: 10.1177/0141076820936491

Abstract: In this first pandemic year of an infectious disease (COVID-19), it seems particularly apt to recall that the foundations for controlling and eventually eradicating another devastating infectious disease – smallpox – began during the 18th… read more here.

Keywords: boylston; medicine; inoculation; smallpox ... See more keywords

John Cross, epidemic theory, and mathematically modeling the Norwich smallpox epidemic of 1819

Sign Up to like & get
recommendations! Published in 2024 at "PLOS ONE"

DOI: 10.1371/journal.pone.0312744

Abstract: In this paper, we reintroduce Dr. John Cross’ neglected and unusually complete historical data set describing a smallpox epidemic occurring in Norwich, England in 1819. We analyze this epidemic data in the context of early… read more here.

Keywords: smallpox; john cross; theory; smallpox epidemic ... See more keywords

Modelling human-to-human transmission of monkeypox

Sign Up to like & get
recommendations! Published in 2020 at "Bulletin of the World Health Organization"

DOI: 10.2471/blt.19.242347

Abstract: Monkeypox is an emerging infectious disease for which outbreak frequency and expected outbreak size in human populations have steadily increased.1 The geographic spread of monkeypox cases has expanded beyond the forests of central Africa, where… read more here.

Keywords: immunity; vaccination; monkeypox; disease ... See more keywords

Human monkeypox — After 40 years, an unintended consequence of smallpox eradication

Sign Up to like & get
recommendations! Published in 2023 at "Frontiers in Public Health"

DOI: 10.3389/fpubh.2022.1082586

Abstract: Monkeypox is one of the many zoonotic viruses that belong to the Orthopoxvirus genus of the Poxviridae family with a similar clinical appearance to smallpox. The symptoms of monkeypox include fever, headache, muscle aches, and… read more here.

Keywords: human monkeypox; smallpox; years unintended; unintended consequence ... See more keywords