Use of live Variola virus to determine whether CAST/EiJ mice are a suitable surrogate animal model for human smallpox.
Sign Up to like & getrecommendations! Published in 2019 at "Virus research"
DOI: 10.1016/j.virusres.2019.197772
Abstract: Numerous animal models of systemic orthopoxvirus disease have been developed to evaluate therapeutics against variola virus (VARV), the causative agent of smallpox. These animal models do not resemble the disease presentation in human smallpox and… read more here.
Keywords: smallpox; model; eij mice; cast eij ... See more keywords
Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2023.2170350
Abstract: ABSTRACT Introduction Tecovirimat oral capsule formulation is approved in the US and Canada for treatment of smallpox and in the United Kingdom (UK) and European Union (EU) for treatment of multiple human orthopoxvirus diseases, including… read more here.
Keywords: mpox; formulation; smallpox; development ... See more keywords
The De Novo Synthesis of Horsepox Virus: Implications for Biosecurity and Recommendations for Preventing the Reemergence of Smallpox.
Sign Up to like & getrecommendations! Published in 2017 at "Health security"
DOI: 10.1089/hs.2017.0061
Abstract: In March 2017, the American biotech company Tonix announced that a Canadian scientist had synthesized horsepox virus as part of a project to develop a safer vaccine against smallpox. The first de novo synthesis of… read more here.
Keywords: smallpox; horsepox; reemergence smallpox; virus ... See more keywords
Reevaluating the Risk of Smallpox Reemergence.
Sign Up to like & getrecommendations! Published in 2020 at "Military medicine"
DOI: 10.1093/milmed/usaa084
Abstract: INTRODUCTION Smallpox, caused by variola virus, was eradicated in 1980, but remains a category A bioterrorism agent. A decade ago, smallpox ranked second after anthrax in a multifactorial risk priority scoring analysis of category A… read more here.
Keywords: category bioterrorism; risk; synthetic biology; smallpox ... See more keywords
Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00927-20
Abstract: Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Smallpox, caused by variola virus (VARV) infection, is highly transmissible, with an estimated 30%… read more here.
Keywords: highly transmissible; brincidofovir; model; monkeypox virus ... See more keywords
Edward Jenner’s 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Royal Society of Medicine"
DOI: 10.1177/0141076818783658
Abstract: Variolation, that is, the inoculation of smallpox material in people who have not experienced natural smallpox, appears to have been a prophylactic used for centuries in much of Asia and North Africa. It was introduced… read more here.
Keywords: 1798 report; jenner 1798; smallpox; variolation ... See more keywords
Probabilistic thinking and evaluation of therapies: an introductory overview
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Royal Society of Medicine"
DOI: 10.1177/0141076820936491
Abstract: In this first pandemic year of an infectious disease (COVID-19), it seems particularly apt to recall that the foundations for controlling and eventually eradicating another devastating infectious disease – smallpox – began during the 18th… read more here.
Keywords: boylston; medicine; inoculation; smallpox ... See more keywords
Modelling human-to-human transmission of monkeypox
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of the World Health Organization"
DOI: 10.2471/blt.19.242347
Abstract: Monkeypox is an emerging infectious disease for which outbreak frequency and expected outbreak size in human populations have steadily increased.1 The geographic spread of monkeypox cases has expanded beyond the forests of central Africa, where… read more here.
Keywords: immunity; vaccination; monkeypox; disease ... See more keywords
Human monkeypox — After 40 years, an unintended consequence of smallpox eradication
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2022.1082586
Abstract: Monkeypox is one of the many zoonotic viruses that belong to the Orthopoxvirus genus of the Poxviridae family with a similar clinical appearance to smallpox. The symptoms of monkeypox include fever, headache, muscle aches, and… read more here.
Keywords: human monkeypox; smallpox; years unintended; unintended consequence ... See more keywords
Smallpox in the Post-Eradication Era
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12020138
Abstract: Widespread vaccination programmes led to the global eradication of smallpox, which was certified by the World Health Organisation (WHO), and, since 1978, there has been no case of smallpox anywhere in the world. However, the… read more here.
Keywords: eradication; post eradication; smallpox post; smallpox ... See more keywords
Genomic Characterization of the Historical Smallpox Vaccine Strain Wyeth Isolated from a 1971 Seed Vial
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v15010083
Abstract: The Wyeth strain of vaccinia virus (VACV) produced by Wyeth Pharmaceuticals was supposedly used to manufacture the old freeze-dried American smallpox vaccine, Dryvax, until its discontinuation in 2008. Although the genomic sequences of numerous Dryvax… read more here.
Keywords: vacv wyeth; smallpox; seed vial; smallpox vaccine ... See more keywords