Effect of prior immunisation with smallpox vaccine for protection against human monkeypox: A systematic review.
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DOI: 10.1002/rmv.2444
Abstract: Monkeypox is an emerging threat to humans since a new outbreak in May 2022. It is hypothesised that increasing the immunologically naive population after the cessation of the smallpox vaccination campaign in the 1980s is… read more here.
Keywords: human monkeypox; smallpox vaccine; smallpox vaccination; risk ... See more keywords
Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects
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DOI: 10.1128/mbio.00102-22
Abstract: Attenuated live viruses make effective vaccines, although concerns exist due to infrequent complications, particularly in individuals with immunological defects. Such complications occurred with smallpox vaccines, which were shown to be comprised of populations of variants.… read more here.
Keywords: receptor; smallpox vaccine; decoy receptor;
Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA
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DOI: 10.1186/s13059-020-02202-0
Abstract: According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century. No information regarding the ends of genomes was presented, and… read more here.
Keywords: smallpox vaccine; nineteenth century; biology; horsepox ... See more keywords
Myocarditis and pericarditis recovery following smallpox vaccine 2002–2016: A comparative observational cohort study in the military health system
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DOI: 10.1371/journal.pone.0283988
Abstract: Objectives (1) Characterize the initial clinical characteristics and long-term outcomes of smallpox vaccine-associated hypersensitivity myocarditis and pericarditis (MP) in United States service members. (2) Describe the process of case identification and adjudication using the 2003… read more here.
Keywords: pericarditis; smallpox vaccine; myocarditis pericarditis; recovery ... See more keywords
Possible Mpox Protection from Smallpox Vaccine–Generated Antibodies among Older Adults
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DOI: 10.3201/eid2903.221231
Abstract: Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71–80 years of age.… read more here.
Keywords: mpox; protection; smallpox vaccine; protection smallpox ... See more keywords
Evaluating the Immunogenicity and Safety of a Smallpox Vaccine to Monkeypox in Healthy Japanese Adults: A Single-Arm Study
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DOI: 10.3390/life13030787
Abstract: Monkeypox (mpox) is an acute exanthematous disease caused by the monkeypox virus (MPXV). Since May 2022, patients with mpox have been reported worldwide, mainly in Europe and the Americas. In Japan, LC16”KMB,” which is a… read more here.
Keywords: safety; immunogenicity; smallpox vaccine; single arm ... See more keywords
Genomic Characterization of the Historical Smallpox Vaccine Strain Wyeth Isolated from a 1971 Seed Vial
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DOI: 10.3390/v15010083
Abstract: The Wyeth strain of vaccinia virus (VACV) produced by Wyeth Pharmaceuticals was supposedly used to manufacture the old freeze-dried American smallpox vaccine, Dryvax, until its discontinuation in 2008. Although the genomic sequences of numerous Dryvax… read more here.
Keywords: vacv wyeth; smallpox; seed vial; smallpox vaccine ... See more keywords