Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.188
Abstract: SMARCA2 is a critical catalytic subunit of the switch/sucrose non-fermenting (SWI/SNF) chromatin remodeling complexes. Dysregulation of SMARCA2 is associated with several diseases, including some cancers. SMARCA2 is multi-domain protein containing a bromodomain (BRD) that specifically… read more here.
Keywords: smarca2 brd; targeting smarca2; throughput screening; smarca2 ... See more keywords
Abstract 2924: Aberrant SWI/SNF complexes lacking SMARCA2 or SMARCA4 differentially affect cell state and response to a novel SMARCA2/4 inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-2924
Abstract: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) is an ATP-dependent DNA helicase and a catalytic component of the SWI/SNF complex. SWI/SNF-mediated nucleosome remodeling is a critical regulator of chromatin accessibility resulting… read more here.
Keywords: swi snf; cell; smarca2; smarca2 smarca4 ... See more keywords
Abstract 6277: Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4- deficient solid tumor
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6277
Abstract: Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to target previously undruggable targets. However, it has been more challenging to identify orally bioavailable TPD molecules due to the physicochemical properties of… read more here.
Keywords: smarca2; orally bioavailable; smarca4 deficient; smarca4 ... See more keywords
NSD2 Interacts with SMARCA2 and Regulates Expression of Oncogenes CCND1 and PRL3 in T(4;14) Multiple Myeloma
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DOI: 10.1182/blood-2018-99-110671
Abstract: Multiple Myeloma (MM), characterized by the uncontrolled proliferation of malignant plasma cells in the bone marrow, occurs mainly in the elderly population. Recurrent chromosomal translocations are central to the pathogenesis of MM, with t(4;14) being… read more here.
Keywords: analysis; multiple myeloma; smarca2; expression ... See more keywords
SMARCA2 is regulated by NORFA/miR-29c, a novel pathway related to female fertility, controls granulosa cell apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.249961
Abstract: SMARCA2, an evolutionarily conserved catalytic ATPase subunit of the SWI/SNF complexes, has been implicated in development and diseases. However, its role in mammalian ovarian function and female fertility is unknown. Here, we identified and characterized… read more here.
Keywords: female fertility; mir 29c; smarca2; apoptosis ... See more keywords