A BAFfling liver aspirate: Metastatic high grade SMARCA4 deficient undifferentiated gastroesophageal junction carcinoma masquerading as a hematolymphoid malignancy
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.24174
Abstract: Undifferentiated malignant SMARCA4‐deficient neoplasms are rare, recently characterized, high grade, potentially lethal malignancies. Such tumors are characterized by the loss of BRG1 encoded by SMARCA4, a key component of the Switch/Sucrose Non‐Fermenting (SWI/SNF) chromatin remodeling… read more here.
Keywords: diagnosis; high grade; smarca4 deficient; deficient ... See more keywords
Usefulness of cell block examination for the cytological diagnosis of thoracic SMARCA4‐deficient undifferentiated tumor: A case report
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25116
Abstract: SMARCA4‐deficient undifferentiated tumor (SMARCA4‐UT) is a high‐grade malignant neoplasm showing undifferentiated or rhabdoid morphology that significantly involves the thorax of adults. It has been reported as SMARCA4‐deficient thoracic sarcoma or SMARCA4‐deficient non‐small cell lung carcinoma… read more here.
Keywords: cell; diagnosis; smarca4 deficient; cell block ... See more keywords
Update on genetically defined lung neoplasms: NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumors
Sign Up to like & getrecommendations! Published in 2021 at "Virchows Archiv"
DOI: 10.1007/s00428-020-03011-3
Abstract: NUT carcinoma, also known as NUT midline carcinoma, is an aggressive malignancy mainly affecting the midline structures of younger patients and almost invariably leading to death within a few months of the diagnosis. Morphologically, NUT… read more here.
Keywords: thoracic smarca4; carcinoma; undifferentiated tumors; nut carcinoma ... See more keywords
SMARCA4-deficient uterine sarcoma: A case report and a concise review
Sign Up to like & getrecommendations! Published in 2020 at "Case Reports in Women's Health"
DOI: 10.1016/j.crwh.2020.e00231
Abstract: Background SMARCA4-deficient uterine sarcoma (SDUS) is a newly discovered undifferentiated uterine mesenchymal malignancy which has loss of expression of SMARCA4. Case A 46-year-old woman presented with heavy irregular vaginal bleeding over the previous 5 months.… read more here.
Keywords: sarcoma case; uterine sarcoma; case; smarca4 deficient ... See more keywords
SMARCA4-deficient thoracic sarcoma: report of a case and insights into how to reach the diagnosis using limited samples and resources.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2017.05.024
Abstract: SMARCA4-deficient thoracic sarcoma is a recently proposed new entity of soft tissue sarcomas with an undifferentiated round cell morphology that is diagnostically challenging. Here we report a case of this tumor where the diagnosis was… read more here.
Keywords: deficient thoracic; diagnosis; limited samples; case ... See more keywords
Patients with SMARCA4-deficient thoracic sarcoma and severe skeletal-related events.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.03.029
Abstract: OBJECTIVES SMARCA4-deficient thoracic sarcoma(DTS) is a recently identified new entity of thoracic malignancies characterized by inactivation of SMARCA4. Patients with SMARCA4-DTS have a particulary aggresive clinical course and no effective treatments. However, the detailed clinical… read more here.
Keywords: deficient thoracic; smarca4; patients smarca4; thoracic sarcoma ... See more keywords
A case of radio-insensitive SMARCA4-deficient thoracic undifferentiated carcinoma with severe right heart failure
Sign Up to like & getrecommendations! Published in 2021 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2021.101364
Abstract: SMARCA4-deficient thoracic sarcomatoid tumors were characterized by inactivating mutations of SMARCA4 and often found in the chest of young and middle-aged males with a smoking history. Recently, SMARCA4-deficient thoracic sarcomatoid tumors were reported to represent… read more here.
Keywords: deficient thoracic; right heart; thoracic; severe right ... See more keywords
SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Modern Pathology"
DOI: 10.1038/s41379-018-0049-z
Abstract: Small cell carcinoma of the ovary, hypercalcemic type is a rare, aggressive malignancy which usually occurs in young women and is characterized by mutations in SMARCA4, with few other alterations. We recently encountered uterine tumors… read more here.
Keywords: sarcoma; carcinoma; uterine sarcoma; cell ... See more keywords
SMARCA4 Deficient Thoracic Sarcoma Presenting with a Pathologic Fracture of Proximal Tibia and L5 Vertebral Body: a Case Report and Review of Literature
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaa161.085
Abstract: SMARCA4 (BRG1) is a central component of the Switch/Sucrose-Non-Fermentable (SWI/SNF) chromatin remodeling complex which plays a critical role in the initiation, progression and dedifferentiation of a variety of cancers arising in different anatomical sites. The… read more here.
Keywords: thoracic sarcoma; deficient thoracic; smarca4 deficient;
Successful treatment with nivolumab for SMARCA4‐deficient non‐small cell lung carcinoma with a high tumor mutation burden: A case report
Sign Up to like & getrecommendations! Published in 2019 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13070
Abstract: SMARCA4 is a subunit of the switch/sucrose non‐fermentable (SWI/SNF) chromatin‐remodeling complex. An effective treatment for SMARCA4‐deficient non‐small cell lung carcinoma (NSCLC) has not yet been established. Correlations between a response to immune checkpoint inhibitors and… read more here.
Keywords: tumor mutation; treatment; smarca4 deficient; high tumor ... See more keywords
Abstract 6277: Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4- deficient solid tumor
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6277
Abstract: Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to target previously undruggable targets. However, it has been more challenging to identify orally bioavailable TPD molecules due to the physicochemical properties of… read more here.
Keywords: smarca2; orally bioavailable; smarca4 deficient; smarca4 ... See more keywords