Abstract 3949: SMARCAL1 is a novel synthetic lethal target in ALT+ osteosarcoma and neuroblastoma
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DOI: 10.1158/1538-7445.am2024-3949
Abstract: Osteosarcoma (OS) is an aggressive pediatric solid tumor that is difficult to treat with established therapies. We performed CRISPR/Cas9 screening in 13 OS cell lines as part of the Dependency Map project. Mining this data… read more here.
Keywords: dependency; smarcal1 novel; smarcal1; atrx ... See more keywords
Abstract B023: SMARCAL1 is a novel candidate therapeutic target for ALT-positive osteosarcoma
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DOI: 10.1158/1538-7445.dnarepair24-b023
Abstract: The DNA translocase SMARCAL1 has been characterized by our laboratory and others as a DNA replication-associated factor that promotes the remodeling of stalled replication forks to facilitate the repair of DNA damage and the restart… read more here.
Keywords: smarcal1 novel; cancer; osteosarcoma; smarcal1 ... See more keywords