Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition
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DOI: 10.7554/elife.44161
Abstract: Renal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. We have developed faithful patient-derived RMC models and using whole-genome sequencing, we identified loss-of-function intronic… read more here.
Keywords: smarcb1 loss; loss; carcinomas depend; renal medullary ... See more keywords