Dual Targeting Smart Drug Delivery System for Multimodal Synergistic Combination Cancer Therapy with Reduced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.06.016
Abstract: This study first reports the development of a smart drug delivery system (DDS) for multimodal synergistic cancer therapy combining chemo-photothermal-starvation approaches. A magnetic photothermal agent was synthesized by preparing iron oxide (IO) nanoparticles (NPs) with… read more here.
Keywords: delivery system; dual targeting; drug delivery; drug ... See more keywords
Hyperthermia and smart drug delivery systems for solid tumor therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2020.02.004
Abstract: Chemotherapy is a cornerstone of cancer therapy. Irrespective of the administered drug, it is crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need to be absorbed, then enter the… read more here.
Keywords: drug delivery; drug; therapy; smart drug ... See more keywords
Externally Addressable Smart Drug Delivery Vehicles: Current Technologies and Future Directions
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.9b01798
Abstract: Growing clinical evidence around the value of delivering drugs with pulsatile, user-controlled, or patient-specific kinetics has recently resulted in extensive efforts toward the design of new functional materials that can enable on-demand externally triggered drug… read more here.
Keywords: externally addressable; externally triggered; drug; smart drug ... See more keywords
Animal simulations facilitate smart drug design through prediction of nanomaterial transport to individual tissue cells
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aax2642
Abstract: A state-of-the-art in vitro to in silico animal body simulation successfully predicts biodistribution with cellular resolution. Smart drug design for antibody and nanomaterial-based therapies allows optimization of drug efficacy and more efficient early-stage preclinical trials.… read more here.
Keywords: drug design; tissue; drug; individual tissue ... See more keywords
Applications of phase change materials in smart drug delivery for cancer treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.991005
Abstract: Phase change materials (PCMs) are materials that are stimulated by the external enthalpy change (temperature) to realize solid-liquid and liquid-solid phase transformation. Due to temperature sensitivity, friendly modification, and low toxicity, PCMs have been widely… read more here.
Keywords: change; phase change; drug delivery; drug ... See more keywords
“Smart” drug delivery: A window to future of translational medicine
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1095598
Abstract: Chemotherapy is the mainstay of cancer treatment today. Chemotherapeutic drugs are non-selective and can harm both cancer and healthy cells, causing a variety of adverse effects such as lack of specificity, cytotoxicity, short half-life, poor… read more here.
Keywords: medicine; drug delivery; drug; smart drug ... See more keywords