Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR‐mediated apical conductance
Sign Up to like & getrecommendations! Published in 2021 at "Physiological Reports"
DOI: 10.14814/phy2.14928
Abstract: The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel whose dysfunction causes cystic fibrosis (CF). The loss of CFTR function in pulmonary epithelial cells causes surface dehydration, mucus build‐up, inflammation, and bacterial infections… read more here.
Keywords: epithelial cells; cftr; smase; anion secretion ... See more keywords
Enhancement of Sphingomyelinase-Induced Endothelial Nitric Oxide Synthase-Mediated Vasorelaxation in a Murine Model of Type 2 Diabetes
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DOI: 10.3390/ijms24098375
Abstract: Sphingolipids are important biological mediators both in health and disease. We investigated the vascular effects of enhanced sphingomyelinase (SMase) activity in a mouse model of type 2 diabetes mellitus (T2DM) to gain an understanding of… read more here.
Keywords: smase; nitric oxide; vasorelaxation; model type ... See more keywords
Effect of Sphingomyelinase-Treated LDLs on HUVECs
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DOI: 10.3390/molecules28052100
Abstract: Low-density lipoproteins (LDLs) exert a key role in the transport of esterified cholesterol to tissues. Among the atherogenic modifications of LDLs, the oxidative modification has been mainly investigated as a major risk factor for accelerating… read more here.
Keywords: treated ldls; effect; smase; effect sphingomyelinase ... See more keywords