QM/MM investigation of substrate binding of subclass B3 metallo-β-lactamase SMB-1 from Serratia marcescents: insights into catalytic mechanism
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DOI: 10.1007/s00894-020-4330-y
Abstract: Metallo-β-lactamases (MβLs) can hydrolyze and deactivate lactam-containing antibiotics, which are the major mechanism to cause drug resistance in the treatment of bacterial infections. This has become a global concern due to the lack of clinically… read more here.
Keywords: substrate binding; mechanism; smb; serratia marcescents ... See more keywords