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   Articles with "smc complexes" as a keyword



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SMC complexes: Lifting the lid on loop extrusion.

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recommendations! Published in 2022 at "Current opinion in cell biology"

DOI: 10.1016/j.ceb.2021.12.003

Abstract: Loop extrusion has emerged as a prominent hypothesis for how SMC complexes shape chromosomes - single molecule in vitro observations have yielded fascinating images of this process. When not extruding loops, SMC complexes are known to… read more here.

Keywords: loop extrusion; smc complexes; extrusion; biology ... See more keywords
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SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109485

Abstract: Structural maintenance of chromosomes (SMCs) complexes, cohesin, condensin, and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair. Here we show that SUMO chains target all… read more here.

Keywords: sumo chain; sumo protease; protease ulp2; smc complexes ... See more keywords
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SMC complexes sweeping through the chromosome: going with the flow and against the tide.

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recommendations! Published in 2018 at "Current opinion in microbiology"

DOI: 10.1016/j.mib.2017.10.004

Abstract: Bacteria transcribe, duplicate and segregate their genomes all at once. Conflicts between DNA replication and active transcription are a major source of DNA damage and jeopardize genome integrity and cell survival. Co-orientation of replication forks… read more here.

Keywords: sweeping chromosome; chromosome going; smc complexes; complexes sweeping ... See more keywords
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XerD unloads bacterial SMC complexes at the replication terminus.

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recommendations! Published in 2021 at "Molecular cell"

DOI: 10.1016/j.molcel.2020.12.027

Abstract: Bacillus subtilis structural maintenance of chromosomes (SMC) complexes are topologically loaded at centromeric sites adjacent to the replication origin by the partitioning protein ParB. These ring-shaped ATPases then translocate down the left and right chromosome… read more here.

Keywords: unloads bacterial; xerd unloads; smc complexes; xerd ... See more keywords
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DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac268

Abstract: Structural Maintenance of Chromosomes (SMC) complexes play essential roles in genome organization across all domains of life. To determine how the activities of these large ( 50 nm) complexes are controlled by ATP binding and… read more here.

Keywords: dna tension; tension; molecular dynamics; smc complexes ... See more keywords
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Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus

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recommendations! Published in 2017 at "Science"

DOI: 10.1126/science.aai8982

Abstract: Tethering DNA for packing purposes Condensin protein complexes are critical for chromosome segregation and compaction. They form ring-shaped structures that encircle and topologically constrain DNA strands. Wang et al. show that Bacillus subtilis condensin complexes… read more here.

Keywords: dna; subtilis smc; smc complexes; bacillus subtilis ... See more keywords
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Organization of Chromosomal DNA by SMC Complexes.

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recommendations! Published in 2019 at "Annual review of genetics"

DOI: 10.1146/annurev-genet-112618-043633

Abstract: Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it… read more here.

Keywords: dna; genetics; dna smc; organization chromosomal ... See more keywords
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Function and Evolution of the Loop Extrusion Machinery in Animals

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24055017

Abstract: Structural maintenance of chromosomes (SMC) complexes are essential proteins found in genomes of all cellular organisms. Essential functions of these proteins, such as mitotic chromosome formation and sister chromatid cohesion, were discovered a long time… read more here.

Keywords: smc complexes; extrusion; evolution loop; function evolution ... See more keywords
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A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis

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recommendations! Published in 2021 at "eLife"

DOI: 10.7554/elife.65467

Abstract: SMC complexes are widely conserved ATP-powered DNA-loop-extrusion motors indispensable for organizing and faithfully segregating chromosomes. How SMC complexes translocate along DNA for loop extrusion and what happens when two complexes meet on the same DNA… read more here.

Keywords: chromosome organization; smc; smc complexes; smc flux ... See more keywords