Smc5/6 Complex Promotes Rad3ATR Checkpoint Signaling at the Perturbed Replication Fork through Sumoylation of the RecQ Helicase Rqh1
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DOI: 10.1128/mcb.00045-22
Abstract: Smc5/6, like cohesin and condensin, is a structural maintenance of chromosomes complex crucial for genome stability. Unlike cohesin and condensin, Smc5/6 carries an essential Nse2 subunit with SUMO E3 ligase activity. ABSTRACT Smc5/6, like cohesin… read more here.
Keywords: sumoylation; replication; checkpoint signaling; rqh1 ... See more keywords
KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system
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DOI: 10.1371/journal.ppat.1010744
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus with the capacity to establish life-long latent infection. During latent infection, the viral genome persists as a circular episome that associates with cellular histones and exists… read more here.
Keywords: smc5 complex; kshv rta; smc5; viral chromatin ... See more keywords
The SMC5/6 complex: An emerging antiviral restriction factor that can silence episomal DNA
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DOI: 10.1371/journal.ppat.1011180
Abstract: Human cells express 3 conformationally similar structural maintenance of chromosome (SMC) complexes called cohesin, condensin, and the SMC5/6 complex [1]. The SMC5/6 complex plays an important role in chromosomal DNA repair, including repair of double-stranded… read more here.
Keywords: dna; maintenance; complex emerging; smc5 complex ... See more keywords
Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6
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DOI: 10.3390/v9040069
Abstract: Hepatitis B X protein (HBx) plays an essential role in the hepatitis B virus (HBV) replication cycle, but the function of HBx has been elusive until recently. It was recently shown that transcription from the… read more here.
Keywords: protein; hepatitis; smc5; hepatitis virus ... See more keywords
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers
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DOI: 10.7554/elife.79676
Abstract: The human SMC5/6 complex is a conserved guardian of genome stability and an emerging component of antiviral responses. These disparate functions likely require distinct mechanisms of SMC5/6 regulation. In yeast, Smc5/6 is regulated by its… read more here.
Keywords: replication centers; slf2; domain; smc5 ... See more keywords