Smc5/6, an atypical SMC complex with two RING-type subunits.
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DOI: 10.1042/bst20200389
Abstract: The Smc5/6 complex plays essential roles in chromosome segregation and repair, by promoting disjunction of sister chromatids. The core of the complex is constituted by an heterodimer of Structural Maintenance of Chromosomes (SMC) proteins that… read more here.
Keywords: two ring; smc; smc5 atypical; smc5 complex ... See more keywords
KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system
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DOI: 10.1371/journal.ppat.1010744
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus with the capacity to establish life-long latent infection. During latent infection, the viral genome persists as a circular episome that associates with cellular histones and exists… read more here.
Keywords: smc5 complex; kshv rta; smc5; viral chromatin ... See more keywords
The SMC5/6 complex: An emerging antiviral restriction factor that can silence episomal DNA
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DOI: 10.1371/journal.ppat.1011180
Abstract: Human cells express 3 conformationally similar structural maintenance of chromosome (SMC) complexes called cohesin, condensin, and the SMC5/6 complex [1]. The SMC5/6 complex plays an important role in chromosomal DNA repair, including repair of double-stranded… read more here.
Keywords: dna; maintenance; complex emerging; smc5 complex ... See more keywords
Multiple Roles of SMC5/6 Complex during Plant Sexual Reproduction
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DOI: 10.3390/ijms23094503
Abstract: Chromatin-based processes are essential for cellular functions. Structural maintenance of chromosomes (SMCs) are evolutionarily conserved molecular machines that organize chromosomes throughout the cell cycle, mediate chromosome compaction, promote DNA repair, or control sister chromatid attachment.… read more here.
Keywords: multiple roles; plant sexual; smc5 complex; plant ... See more keywords