SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization
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DOI: 10.1042/bcj20210278
Abstract: Structural maintenance of chromosomes flexible hinge domain-containing 1 (SMCHD1) is an epigenetic regulator that mediates gene expression silencing at targeted sites across the genome. Our current understanding of SMCHD1's molecular mechanism, and how substitutions within… read more here.
Keywords: like domain; chromatin; smchd1; dimerization ... See more keywords
Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures
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DOI: 10.1093/hmg/ddy173
Abstract: Facioscapulohumeral muscular dystrophy (FSHD) is caused by insufficient epigenetic repression of D4Z4 macrosatellite repeat where DUX4, an FSHD causing gene is embedded. There are two forms of FSHD, FSHD1 with contraction of D4Z4 repeat and… read more here.
Keywords: small noncoding; muscle; muscle cells; noncoding rnas ... See more keywords