Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR.
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DOI: 10.1021/acsinfecdis.0c00587
Abstract: An antivirulence agent against Vibrio vulnificus named quoromycin (QM) was discovered by a phenotype-based elastase inhibitor screening. Using the fluorescence difference in two-dimensional gel electrophoresis (FITGE) approach, SmcR, a quorum-sensing master regulator and homologue of… read more here.
Keywords: quorum sensing; smcr; antivirulence agent; vulnificus ... See more keywords