Regulation of SMC traction forces in human aortic thoracic aneurysms
Sign Up to like & getrecommendations! Published in 2021 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-020-01412-6
Abstract: Smooth muscle cells (SMCs) usually express a contractile phenotype in the healthy aorta. However, aortic SMCs have the ability to undergo profound changes in phenotype in response to changes in their extracellular environment, as occurs… read more here.
Keywords: smcs; smc traction; regulation smc; traction ... See more keywords
Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111589
Abstract: Abdominal aortic aneurysms (AAA) are characterized by matrix remodeling, elastin degradation, absence of nitric oxide (NO) signaling, and inflammation, influencing smooth muscle cell (SMC) phenotype and gene expression. Little is known about the biomolecular release… read more here.
Keywords: phenotype gene; smcs; gene expression; aaa smcs ... See more keywords
AFM Stiffness Mapping in Human Aortic Smooth Muscle Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4053657
Abstract: Aortic Smooth Muscle Cells (SMCs) play a vital role in maintaining mechanical homeostasis in the aorta. We recently found that SMCs of aneurysmal aortas apply larger traction forces than SMCs of healthy aortas. This result… read more here.
Keywords: aortic smooth; muscle cells; stiffness; smcs ... See more keywords
Visfatin-Induced Smooth Muscle Cell Stiffness Syndrome during Lysosomal Acid Ceramidase Deficiency
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733235
Abstract: Recent studies have reported that intrinsic stiffness of smooth muscle cells (SMCs) plays an important role in contributing to arterial wall stiffness, which led to the concept of smooth muscle cell stiffness syndrome (SMCSS). However,… read more here.
Keywords: stiffness; microscopy; smcs; physiology ... See more keywords
Piezo1 mediated calcium-calcineurin signaling pathway regulates gastrointestinal smooth muscle cell phenotype in a stiffness dependent manner
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.2106
Abstract: Background: Gastrointestinal (GI) disorders like chronic constipation are more prevalent with aging. Aging GI tract becomes stiffer and exhibits delayed GI transit. Smooth muscle cells (SMCs) are involved in controlling GI transit and show reduced… read more here.
Keywords: smcs; smtn fold; physiology; piezo1 ... See more keywords
Abstract Or131: Novel epigenetic therapy for Smooth Muscle Dysfunction Syndrome
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.or131
Abstract: Missense pathogenic variants in ACTA2, encoding α-smooth muscle actin (SMA), predispose to thoracic aortic aneurysms, but pathogenic variants affecting the specific amino acid arginine 179 (R179) cause a more severe childhood onset phenotype termed Smooth… read more here.
Keywords: smcs; muscle; acta2; muscle dysfunction ... See more keywords
PAI-1 Regulates the Cytoskeleton and Intrinsic Stiffness of Vascular Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.124.320938
Abstract: BACKGROUND: Plasma concentration of PAI-1 (plasminogen activator inhibitor-1) correlates with arterial stiffness. Vascular smooth muscle cells (SMCs) express PAI-1, and the intrinsic stiffness of SMCs is a major determinant of total arterial stiffness. We hypothesized… read more here.
Keywords: smcs; pai; inhibition; intrinsic stiffness ... See more keywords
Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.124.321706
Abstract: BACKGROUND: Smooth muscle cells (SMCs) of cardiac and neural crest origin contribute to the developing proximal aorta and are linked to disease propensity in adults. METHODS: We analyzed single-cell transcriptomes of aortic SMCs from adult… read more here.
Keywords: smcs; cluster; tgf; crest ... See more keywords
Genomic, Transcriptomic, and Proteomic Depiction of Induced Pluripotent Stem Cells–Derived Smooth Muscle Cells As Emerging Cellular Models for Arterial Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.19733
Abstract: Background: Vascular smooth muscle cells (SMCs) plasticity is a central mechanism in cardiovascular health and disease. We aimed at providing cellular phenotyping, epigenomic and proteomic depiction of SMCs derived from induced pluripotent stem cells and… read more here.
Keywords: pluripotent stem; smcs; induced pluripotent; smooth muscle ... See more keywords
Distinct patterns of responses in endothelial cells and smooth muscle cells following vascular injury
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.153769
Abstract: Vascular smooth muscle cells (SMCs) are heterogeneous, and their differential responses to vascular injury are not well understood. To address this question, we performed single-cell analysis of vascular cells to a ligation injury in mouse… read more here.
Keywords: cell; vascular injury; endothelial cells; smcs ... See more keywords
Neuropilin-1 deficiency in vascular smooth muscle cells is associated with hereditary hemorrhagic telangiectasia arteriovenous malformations
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155565
Abstract: Patients with hereditary hemorrhagic telangiectasia (HHT) have arteriovenous malformations (AVMs) with genetic mutations involving the activin-A receptor like type 1 (ACVRL1 or ALK1) and endoglin (ENG). Recent studies have shown that Neuropilin-1 (NRP-1) inhibits ALK1.… read more here.
Keywords: muscle cells; hemorrhagic telangiectasia; smcs; hereditary hemorrhagic ... See more keywords