Regulation of SMC traction forces in human aortic thoracic aneurysms
Sign Up to like & getrecommendations! Published in 2021 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-020-01412-6
Abstract: Smooth muscle cells (SMCs) usually express a contractile phenotype in the healthy aorta. However, aortic SMCs have the ability to undergo profound changes in phenotype in response to changes in their extracellular environment, as occurs… read more here.
Keywords: smcs; smc traction; regulation smc; traction ... See more keywords
Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111589
Abstract: Abdominal aortic aneurysms (AAA) are characterized by matrix remodeling, elastin degradation, absence of nitric oxide (NO) signaling, and inflammation, influencing smooth muscle cell (SMC) phenotype and gene expression. Little is known about the biomolecular release… read more here.
Keywords: phenotype gene; smcs; gene expression; aaa smcs ... See more keywords
AFM Stiffness Mapping in Human Aortic Smooth Muscle Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4053657
Abstract: Aortic Smooth Muscle Cells (SMCs) play a vital role in maintaining mechanical homeostasis in the aorta. We recently found that SMCs of aneurysmal aortas apply larger traction forces than SMCs of healthy aortas. This result… read more here.
Keywords: aortic smooth; muscle cells; stiffness; smcs ... See more keywords
Visfatin-Induced Smooth Muscle Cell Stiffness Syndrome during Lysosomal Acid Ceramidase Deficiency
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733235
Abstract: Recent studies have reported that intrinsic stiffness of smooth muscle cells (SMCs) plays an important role in contributing to arterial wall stiffness, which led to the concept of smooth muscle cell stiffness syndrome (SMCSS). However,… read more here.
Keywords: stiffness; microscopy; smcs; physiology ... See more keywords
Genomic, Transcriptomic, and Proteomic Depiction of Induced Pluripotent Stem Cells–Derived Smooth Muscle Cells As Emerging Cellular Models for Arterial Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.19733
Abstract: Background: Vascular smooth muscle cells (SMCs) plasticity is a central mechanism in cardiovascular health and disease. We aimed at providing cellular phenotyping, epigenomic and proteomic depiction of SMCs derived from induced pluripotent stem cells and… read more here.
Keywords: pluripotent stem; smcs; induced pluripotent; smooth muscle ... See more keywords
Distinct patterns of responses in endothelial cells and smooth muscle cells following vascular injury
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.153769
Abstract: Vascular smooth muscle cells (SMCs) are heterogeneous, and their differential responses to vascular injury are not well understood. To address this question, we performed single-cell analysis of vascular cells to a ligation injury in mouse… read more here.
Keywords: cell; vascular injury; endothelial cells; smcs ... See more keywords
Neuropilin-1 deficiency in vascular smooth muscle cells is associated with hereditary hemorrhagic telangiectasia arteriovenous malformations
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155565
Abstract: Patients with hereditary hemorrhagic telangiectasia (HHT) have arteriovenous malformations (AVMs) with genetic mutations involving the activin-A receptor like type 1 (ACVRL1 or ALK1) and endoglin (ENG). Recent studies have shown that Neuropilin-1 (NRP-1) inhibits ALK1.… read more here.
Keywords: muscle cells; hemorrhagic telangiectasia; smcs; hereditary hemorrhagic ... See more keywords
Dextran sodium sulphate (DSS)-induced colitis alters the expression of neurotrophins in smooth muscle cells of rat colon.
Sign Up to like & getrecommendations! Published in 2017 at "Physiological research"
DOI: 10.33549/physiolres.933465
Abstract: Neurotrophins are present in the gastrointestinal tract where they participate in the survival and growth of enteric neurons, augmentation of enteric circuits, elevation of colonic myoelectrical activity and also in different aspects of colitis. Previous… read more here.
Keywords: smcs; muscle; dss induced; colitis ... See more keywords
Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.925777
Abstract: Cardiovascular calcification is the lead predictor of cardiovascular events and the top cause of morbidity and mortality worldwide. To date, only invasive surgical options are available to treat cardiovascular calcification despite the growing understanding of… read more here.
Keywords: cell; calcification; smcs; cardiovascular calcification ... See more keywords
Age-dependent phenotypic modulation of smooth muscle cells in the normal ascending aorta
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1114355
Abstract: Objectives Ascending aortic aneurysms are associated with pre-existing conditions, including connective tissue disorders (i.e., Marfan syndrome) and bicuspid aortic valves. The underlying mechanisms remain uncertain. Even less is known regarding ascending aortic aneurysms in individuals… read more here.
Keywords: modulation; ascending aortic; smcs; age ... See more keywords